Bioequivalence and Bioavailability Forum

Thanks Helmut,

Yes the saga continues, same beast... The question is when we run Proc GLM, we use the MSE (there is only 1 which is a composite of both test and reference since it's a T vs R study) to get the intrasubject CV and eventually work out the 90% CI goal post. With Proc Mixed in a partial rep study (T vs R vs R), as shown in my first post with the Covariance Matrix, there are two residuals, one for test and one for reference. Is the test residual similar to the total MSE we get from a T vs R study (Meaning the value is attributed to both products)?

I will post the same dataset (more subjects since I have 100% data). It's even stranger now... Stay tune

PS. Please see my original post (the one which I posted the data).

Thanks
John