Bioequivalence and Bioavailability Forum • SAS vs. PHX

SAS vs. PHX [RSABE / ABEL]

posted by Helmut – Vienna, Austria, 2013-04-23 00:10 (4403 d 19:29 ago) – Posting: # 10466
Views: 25,340

Hi John,

❝ My SAS SCABE for this parameter is

❝ Theta Bound y (S2wr) (sWR) (T/R) Pt Est 95% Upper Crit

❝ 0.79669 -0.22198 0.41135 0.64137 89.8994 -0.18423

No need to post Theta (a constant in RSABE). ;-)

My PHX6.3 code gives for RSABE …

boundy     S²wr     Swr       PE       95% upper

-0.221998  0.41138  0.64139  89.8990  -0.18424336

❝ I ran Unscaled Avg BE (Progesterone guidance SAS code)

❝ T/R Ratio 90% CI

❝ 101.021 80.7739 - 126.343

… and for ABE

  PE          90% CI

104.782  69.7855 – 157.328

But: PHX’ LME kicked my ass with “Warning 11094: Negative final variance component. Consider omitting this VC structure.” Nice. Old story with partial replicates – overspecified model since T is not repeated. We have seen in the past that SAS and PHX give different results in such a case. BTW, did you get “Convergence criteria met but final hessian is not positive definite.” or somefink sⁱm_il^a_r in Sas?

If I go with the ABE-module I got:
“ERROR 11070: Error in Satterthwaite DF. Try using Residual DF option.”
… which I tried, only to get:
“ERROR 11070: Error in Satterthwaite DF. Try using Residual DF option.”
That’s funny! Same if I exclude subjects #14 and #31 (no results for T). What the heck?

Running PHX’ PBE/IBE module I first obtained …

Warning 11121: Subject 31 had incomplete design and was discarded.

Warning 11121: Subject 14 had incomplete design and was discarded.

Warning 11121: Subject 8 had incomplete design and was discarded.

Warning 11121: Subject 17 had incomplete design and was discarded.

… and a PE which is exactly like in RSABE 89.899043.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

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Complete thread:

FDA's HVD SAS Code from Progesterone Guidance jag009 2013-04-22 16:39
- Proc MIXED vs. Proc GLM Helmut 2013-04-22 17:47
  - Proc MIXED vs. Proc GLM jag009 2013-04-22 20:33
    - SAS vs. PHXHelmut 2013-04-22 22:10
      - SAS vs. PHX Shuanghe 2013-04-23 11:45
        
        SAS vs. SAS d_labes 2013-04-23 16:50
        
        SAS vs. SAS vs. Phoenix Helmut 2019-11-12 13:01
      - SAS vs. PHX jag009 2013-04-23 15:56
        
        SAS Warning (Note) on Proc Mixed jag009 2013-04-23 17:07
        
        Nut Job.. jag009 2013-04-30 21:09
        
        Second opinion (PHX 6.3) Helmut 2013-05-01 16:21
        
        Second opinion (PHX 6.3) jag009 2013-05-01 17:16
        
        Second opinion (PHX 6.3) ElMaestro 2013-05-01 18:48
        In praise of a full replicate Helmut 2013-05-01 19:16
        Third opinion d_labes 2013-05-02 12:00
        
        Compound Symmetry Helmut 2013-05-02 14:41
        
        Compound Symmetry - SASian (1) d_labes 2013-05-02 16:26
        
        Variance=0 Helmut 2013-05-03 16:07