Bioequivalence and Bioavailability Forum • Proc MIXED vs. Proc GLM

Proc MIXED vs. Proc GLM [RSABE / ABEL]

posted by Helmut – Vienna, Austria, 2013-04-22 19:47 (4404 d 10:01 ago) – Posting: # 10460
Views: 25,680

Hi John,

❝ Should the Test/Reference Ratio from the Scaled Average BE computation be similar (if not the same) as the ratio computed from the above Unscaled Average BE code?

More details, pleeze! Define similar. ;-)

Note that FDA’s ABE is evaluated by a Proc MIXED and the partial replicate by Proc GLM. You will see differences for incomplete data-sets (GLM drops subjects, MIXED keeps them).

Even for a fully replicated design (but imbalanced and incomplete like EMA’s data set I) SAS’ merge will drop subjects. In Phoenix I get PEs of 1.1546132 (RSABE) and 1.1565765 (ABE).

—
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Helmut Schütz

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Complete thread:

FDA's HVD SAS Code from Progesterone Guidance jag009 2013-04-22 16:39
- Proc MIXED vs. Proc GLMHelmut 2013-04-22 17:47
  - Proc MIXED vs. Proc GLM jag009 2013-04-22 20:33
    - SAS vs. PHX Helmut 2013-04-22 22:10
      - SAS vs. PHX Shuanghe 2013-04-23 11:45
        
        SAS vs. SAS d_labes 2013-04-23 16:50
        
        SAS vs. SAS vs. Phoenix Helmut 2019-11-12 13:01
      - SAS vs. PHX jag009 2013-04-23 15:56
        
        SAS Warning (Note) on Proc Mixed jag009 2013-04-23 17:07
        
        Nut Job.. jag009 2013-04-30 21:09
        
        Second opinion (PHX 6.3) Helmut 2013-05-01 16:21
        
        Second opinion (PHX 6.3) jag009 2013-05-01 17:16
        
        Second opinion (PHX 6.3) ElMaestro 2013-05-01 18:48
        In praise of a full replicate Helmut 2013-05-01 19:16
        Third opinion d_labes 2013-05-02 12:00
        
        Compound Symmetry Helmut 2013-05-02 14:41
        
        Compound Symmetry - SASian (1) d_labes 2013-05-02 16:26
        
        Variance=0 Helmut 2013-05-03 16:07