Bioequivalence and Bioavailability Forum • Confusing…

Confusing… [RSABE / ABEL]

posted by jag009 – NJ, 2013-04-04 19:21 (4423 d 10:48 ago) – Posting: # 10346
Views: 9,660
(edited on 2013-04-04 22:15)

Helmut, here is the issue with Dlat analysis between mine and CRO's. The 2 GLM procedure output are different but the Ratio, 95% Upper Bound, SwRs are ok. :confused:

However, my GLM procedure output for ilat analysis shows same results as those from the CRO.

My output.

scaled average BE - analysis of dlat for ln(Cmax)

The GLM Procedure

Dependent Variable: dlat_lcmax

Source          DF  Sum of Squares  Mean Square   F Value  Pr > F

Model            2    0.17972168     0.08986084    0.28    0.7588

Error           66   21.40250828     0.32428043

Corrected Total 68 21.58222996



R-Square Coeff Var  Root MSE  dlat_lcmax Mean

0.008327 -322.9433  0.569456    -0.176333



Source     DF   Type I SS     Mean Square  F Value  Pr > F

sequence   2    0.17972168    0.08986084    0.28    0.7588

Source     DF   Type III SS   Mean Square  F Value  Pr > F

sequence   2    0.17972168    0.08986084    0.28    0.7588



Theta   Within Subject   Within Subject   Pt Est.   95% Uppder 

          Var of Ref      SD of Ref        (T/R)    Conf. Bnd

0.79669    0.16214         0.40267        150.848     0.15460

CRO output

scaled average BE - analysis of dlat for ln(Cmax)

The GLM Procedure

Dependent Variable: dlat_lcmax

Source            DF    Sum of Squares   Mean Square  F Value  Pr > F

Model              2      2.06868456      1.03434228    3.19   0.0476

Error             66     21.40251551      0.32428054

Corrected Total   68     23.47120008



R-Square  Coeff Var   Root MSE   dlat_lcmax Mean

0.088137  -933.9983   0.569456   -0.060970



Source   DF   Type I SS     Mean Square  F Value   Pr > F

SEQ      2    2.06868456    1.03434228     3.19    0.0476

Source   DF   Type III SS   Mean Square  F Value   Pr > F

SEQ      2    2.06868456    1.03434228     3.19    0.0476



Obs   RATIO   theta        y       boundy    sWR      critbound

1    150.848  0.79669  -0.12918 -0.099175   0.40267    0.15460

Complete thread:

SAS Procedure on Partial Replicate (TRR) Study Data jag009 2013-04-02 21:11
- Confusing… Helmut 2013-04-03 13:42
  - Confusing… jag009 2013-04-03 16:06
    - Confusing… Helmut 2013-04-03 21:49
      - Confusing… jag009 2013-04-03 23:01
        
        Confusing… Helmut 2013-04-03 23:22
        
        Confusing… jag009 2013-04-04 15:59
        Confusing…jag009 2013-04-04 17:21
        
        2nd opinion Helmut 2013-04-05 01:01
        
        2nd opinion jag009 2013-04-05 15:24
        
        3rd, 4th opinion d_labes 2013-04-05 11:04
        
        3rd, 4th opinion jag009 2013-04-05 15:41
        
        Beer swaped d_labes 2013-04-05 16:09
        
        Beer swaped jag009 2013-04-05 17:18