Bioequivalence and Bioavailability Forum • Ach du lieber

Ach du lieber [Two-Stage / GS Designs]

posted by ElMaestro – Denmark, 2012-10-23 22:51 (4624 d 23:36 ago) – Posting: # 9455
Views: 7,014

Hi Helmut,

❝ Not quite. You are mixing two things up, IMHO. T/R is an assumption – not “known”.

Not quite. You are mixing two things up, IMHO :-D

When we do simulations, we know the exact T/R we are simulating. This is the situation I am talking about here. My question is not related to the situation of an applicant conducting a two-stage trial when T/R is estimated and never known.
My thought was prolly a bad idea anyway. A shift in T or R (location?!) will affect the minimised SS, albeit if we tamper with it that way I no longer know if the resulting s derived from minimisation of SS will be unbiased. In principle the latter issue is of less importance for me if it turns out the type I error or power is improved.

—
Pass or fail!
ElMaestro

Complete thread:

2-stage maximum likelihood of CV/RMSE, given T/R ElMaestro 2012-10-22 15:06
- Not sure whether I understand this Helmut 2012-10-22 15:40
  - Not sure whether I understand this ElMaestro 2012-10-22 16:34
    - Not sure whether I understand this d_labes 2012-10-23 16:44
      - Not sure whether I understand this ElMaestro 2012-10-23 16:55
        
        Not sure whether I understand this Helmut 2012-10-23 17:17
        
        Ach du lieberElMaestro 2012-10-23 20:51