Bioequivalence and Bioavailability Forum • 2-stage maximum likelihood of CV/RMSE, given T/R

2-stage maximum likelihood of CV/RMSE, given T/R [Two-Stage / GS Designs]

posted by ElMaestro – Denmark, 2012-10-22 17:06 (4626 d 02:48 ago) – Posting: # 9442
Views: 8,179

Dear all,

as usual I am fiddling with my compiler. And no, this is not a metaphore. At least not this time.

What I am thinking at present is this: For Potvin method B/C/D we use the CV from stage 1 in the sample size estimation for stage 2, but we do not use the observed T/R; in stead we use fixed T/R=0.9 or 0.95 etc. On the other hand we do use observed T/R when we test for BE at both stages.

So, let's be consequent and propose we will use the fixed T/R of 0.90 or 0.95 for evaluation of BE at stage 1 and dimensioning of st. 2. To do this we must then find the maximum likelihood of the anova RMSE (s, CV) given the model, the fixed T/R ratio and the observations. Can anyone suggest how to accomplish that?

Many thanks for any input.

—
Pass or fail!
ElMaestro

Complete thread:

2-stage maximum likelihood of CV/RMSE, given T/RElMaestro 2012-10-22 15:06
- Not sure whether I understand this Helmut 2012-10-22 15:40
  - Not sure whether I understand this ElMaestro 2012-10-22 16:34
    - Not sure whether I understand this d_labes 2012-10-23 16:44
      - Not sure whether I understand this ElMaestro 2012-10-23 16:55
        
        Not sure whether I understand this Helmut 2012-10-23 17:17
        
        Ach du lieber ElMaestro 2012-10-23 20:51