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Registeradjusted alpha by sims? [Two-Stage / GS Designs]
Dear Helmut!
Don't overheat your machines
.
If you mean Method D I guess: also from some trial and error.
Do you think doing some simulations in the planning phase and deciding the alpha's based on them will be acceptable to the mighty oracles in Europe?
What if the CV comes out other than supposed in the planning?
BTW: It's a similar question a good friend of our ol' pirate EM was once asked in respect to his method (see paper 6 of your post above):
"Do you think that it is acceptable to any regulator in Europe that the alpha of stage 2 isn't chosen a priori but depending on the results of stage 1, again via some simulation studies?"
❝ 106 sims of Method B with αadj. 0.0380 (= quick-shot obtained from 104 sims) are running…
Don't overheat your machines
.❝ BTW, where do you think Method B’s 0.0280 came from? 
If you mean Method D I guess: also from some trial and error.
Do you think doing some simulations in the planning phase and deciding the alpha's based on them will be acceptable to the mighty oracles in Europe?
What if the CV comes out other than supposed in the planning?
BTW: It's a similar question a good friend of our ol' pirate EM was once asked in respect to his method (see paper 6 of your post above):
"Do you think that it is acceptable to any regulator in Europe that the alpha of stage 2 isn't chosen a priori but depending on the results of stage 1, again via some simulation studies?"
—
Regards,
Detlew
Regards,
Detlew
Complete thread:
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- two-stage design power 90% in sample size adaption Yvonne 2012-08-02 12:06
- two-stage design power 90% in sample size adaption ElMaestro 2012-08-02 11:29
- Are simulations sufficient? …lenghty post! Helmut 2012-08-02 17:39
- adjusted alpha = 0.045 d_labes 2012-08-03 11:33
- adjusted alpha = 0.038 Helmut 2012-08-03 14:26
- adjusted alpha by sims?d_labes 2012-08-03 15:48
- Yeah but, no but, yeah but, no but… Helmut 2012-08-03 16:39
- Yeah but, no but ... d_labes 2012-08-07 14:42
- Yeah but, no but ... Helmut 2012-08-07 15:14
- Yeah but, no but ... d_labes 2012-08-07 14:42
- Yeah but, no but, yeah but, no but… Helmut 2012-08-03 16:39
- adjusted alpha by sims?d_labes 2012-08-03 15:48
- adjusted alpha = 0.038 Helmut 2012-08-03 14:26
- adjusted alpha = 0.045 d_labes 2012-08-03 11:33
- two-stage design power 90% second stage ElMaestro 2012-08-02 10:17
Ing. Helmut Schütz