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Register2-Stage design [Two-Stage / GS Designs]
Dear all,
Please clarify following Criteria,
We are going to conduct one "Two-Stage" bioequivalence study. In this study initially we had fixed the sample size as maximum of 80 subjects (Both stage1 and stage2).
In stage-1 we include 40 subjects and based on stage1 data we will precede with a maximum sample size of 40 subjects in stage-2 (sample size will be ≤ 40).
Is there any statistical method to decide sample size in stage2?
Regards
Kotu
Edit: Category and subject line changed. [Helmut]
Please clarify following Criteria,
We are going to conduct one "Two-Stage" bioequivalence study. In this study initially we had fixed the sample size as maximum of 80 subjects (Both stage1 and stage2).
In stage-1 we include 40 subjects and based on stage1 data we will precede with a maximum sample size of 40 subjects in stage-2 (sample size will be ≤ 40).
Is there any statistical method to decide sample size in stage2?
Regards
Kotu
Edit: Category and subject line changed. [Helmut]
Complete thread:
- 2-Stage designbalakotu 2012-06-21 08:28
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Sequential design, maximum sample size in stage 2 Helmut 2012-06-21 16:05
- Sequential design, maximum sample size in stage 2 ElMaestro 2012-06-22 01:43
- Well roared, lion d_labes 2012-06-22 08:45
- Sequential design, maximum sample size in stage 2 Helmut 2012-06-21 16:05
Ing. Helmut Schütz