Two-stage design approach [Two-Stage / GS Designs]

posted by balakotu – India, 2012-06-20 09:18 (5112 d 08:25 ago) – Posting: # 8812
Views: 6,001

Dear All,

Please clarify following Criteria with respect to Partial and full replicate study designs?
  1. Is it possible to conduct Two-stage design approach (Method C Potvin et al.) for Partial and full replicate study designs? In this type of designs how to calculate sample size for Stage-2?

  2. It is not possible to calculate Power for USA the Partial and full replicate studies in SAS Program how to calculate power for such study designs?

  3. Whether group*treatment interaction should be statistically insignificant are not (for Europe and Canada Guidelines not mentioned whether it is required are not).

  4. Please specify the most suitable conditions to opt Two-Stage design?

Regards
Kotu

Complete thread:

UA Flag
Activity
 Admin contact
23,654 posts in 4,992 threads, 1,570 registered users;
167 visitors (0 registered, 167 guests [including 23 identified bots]).
Forum time: 17:44 CEST (Europe/Vienna)

Actually, science starts to become interesting
only where it ends.    Justus von Liebig

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5