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RegisterPotvin C not acceptable! [Two-Stage / GS Designs]
Dear Outlaw!
Regulators are a strange bunch
.
Seems they (whoever that is) have taken the 5% literally and do not accept the empirical overall alpha values in method C which are slightly above 5% around CV = 10 to 20%.
Potvin et al. have pointed out clearly that the excess is not at least due to the simulation methodology and may vanish if the number of simulated studies will be raised. Therefore the authors have decided to take only alpha inflation greater then 5.2% as serious (real).
Seems they have not read this or are "päpstlicher als der Pabst" (They are more Catholic than the pope).
Seems this compared to Helmut's experience is a case of ElMaestros "variable constants"
.
❝ We provided our protocol to a central European country and this is what they responded about Potvin method C:
❝
❝ “Method C” as proposed in this publication is not acceptable, as type I error is not controlled on the 5% level and alternative methods securing type I error control are available.
Regulators are a strange bunch
.Seems they (whoever that is) have taken the 5% literally and do not accept the empirical overall alpha values in method C which are slightly above 5% around CV = 10 to 20%.
Potvin et al. have pointed out clearly that the excess is not at least due to the simulation methodology and may vanish if the number of simulated studies will be raised. Therefore the authors have decided to take only alpha inflation greater then 5.2% as serious (real).
Seems they have not read this or are "päpstlicher als der Pabst" (They are more Catholic than the pope).
Seems this compared to Helmut's experience is a case of ElMaestros "variable constants"
.—
Regards,
Detlew
Regards,
Detlew
Complete thread:
- Two-Stage Sequential Designs Helmut 2010-05-20 16:53
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Two-Stage Sequential Designs yjlee168 2010-05-20 21:28
- Two-Stage Sequential Designs Helmut 2010-05-21 01:06
- EMA: Two-Stage Sequential Designs d_labes 2010-06-15 16:02
- EMA: Two-Stage Sequential Designs Helmut 2010-06-15 16:23
- EMA: Two-Stage Sequential Designs The Outlaw Torn 2011-10-20 10:30
- EMA: Two-Stage Sequential Designs Helmut 2011-10-21 15:01
- PAR? ElMaestro 2011-10-21 15:23
- PAR not yet Helmut 2011-10-21 16:02
- PAR not yet The Outlaw Torn 2011-10-25 08:57
- PAR not yet The Outlaw Torn 2011-10-27 11:07
- Potvin C not acceptable!d_labes 2011-10-27 13:16
- PAR not yet ElMaestro 2011-10-27 13:25
- PAR not yet The Outlaw Torn 2011-10-31 07:45
- No (?) comment :-( Helmut 2011-10-31 15:04
- PAR not yet The Outlaw Torn 2011-10-31 07:45
- PAR not yet The Outlaw Torn 2011-10-27 11:07
- PAR not yet The Outlaw Torn 2011-10-25 08:57
- PAR not yet Helmut 2011-10-21 16:02
- PAR? ElMaestro 2011-10-21 15:23
- EMA: Two-Stage Sequential Designs Helmut 2011-10-21 15:01
- EMA: Two-Stage Sequential Designs The Outlaw Torn 2011-10-20 10:30
- EMA: Two-Stage Sequential Designs Helmut 2010-06-15 16:23
- EMA: Two-Stage Sequential Designs d_labes 2010-06-15 16:02
- Two-Stage Sequential Designs Helmut 2010-05-21 01:06
- Two-Stage Sequential Designs yjlee168 2010-05-20 21:28
Ing. Helmut Schütz