Bioequivalence and Bioavailability Forum

Need for speed... [Two-Stage / GS Designs]

posted by d_labes  – Berlin, Germany, 2011-02-15 15:06 (5241 d 09:04 ago) – Posting: # 6624
Views: 26,617

Dear Old Pirate!

❝ 1.000.000 sims at CV=0.3 and n1=36 method B takes [Praise C]45 seconds[/Praise C] on my laptop using Mersenne Twister as my NLYW.

Wow! That's really fast!

❝ ... They seem to use a funny way to calculate power; I bet the magnificent package power.TOST can do it better.

Of course ! But remember my post to find out that the approximations work reasonable good for the decision power>=80% or power<80%. But if approximate I would go for the non-central t-distribution.

Do you think that your C-code can made interacting with R to facilitate such things as other methods for sample size adaption, other nominal alpha values for the two stages, introduction of a maximum number of subjects ... ?

Complete thread:

• Potvin method B subtleties d_labes 2011-01-31 14:24 
  • Potvin method B subtleties jdetlor 2011-02-01 17:17
    • Potvin method B subtleties d_labes 2011-02-02 09:15
      • Potvin method B subtleties jdetlor 2011-02-02 16:08
        • Gould d_labes 2011-02-02 16:25
          • Gould jdetlor 2011-02-02 17:02
  • Another one ... d_labes 2011-02-07 14:32
    • Oops! Helmut 2011-02-07 15:24
      • Oops! d_labes 2011-02-07 16:29
        • Oops! Helmut 2011-02-07 16:47
          • Oops! ElMaestro 2011-02-07 17:06
            • Oops! Helmut 2011-02-07 17:17
              • Oops! ElMaestro 2011-02-07 18:35
          • Simul'ants in my pants d_labes 2011-02-08 09:07
            • Need for speed... ElMaestro 2011-02-13 10:57
              • Need for speed...d_labes 2011-02-15 14:06
                • Need for speed... ElMaestro 2011-02-15 17:39
                  • Pocock alpha's d_labes 2011-02-16 09:18
                    • ElMaestro's brain ElMaestro 2011-02-16 09:32
                      • ElMaestro's brain d_labes 2011-02-16 10:05
                        • ElMaestro's brain ElMaestro 2011-02-16 12:07
                          • Numbers d_labes 2011-02-16 13:45
  • Bonus counter-question ElMaestro 2011-02-07 23:44
    • Speed is the question d_labes 2011-02-08 08:36
  • New paper (method D for PE 0.90) Helmut 2011-04-18 12:58
    • New paper (method D for PE 0.90) d_labes 2011-04-19 08:58
      • New paper (method D for PE 0.90) Helmut 2011-04-19 14:30
      • New paper (method D for PE 0.90) ElMaestro 2011-04-19 14:49
        • Stopping criterion # futility rule Helmut 2011-04-19 15:28