Bioequivalence and Bioavailability Forum • Another one ...

Another one ... [Two-Stage / GS Designs]

posted by d_labes – Berlin, Germany, 2011-02-07 15:32 (5611 d 13:56 ago) – Posting: # 6567
Views: 31,473

Dear All,

Potvin et. al. describe the use of GMR = 0.95 in the sample size adaption step of their Methods B/C. If we assume a more extreme null ratio and want to calculate the empirical power at that GMR (via simulation):
Is it reasonable / mandatory to use that GMR in the sample size adaption step? :ponder:

—
Regards,

Detlew

Complete thread:

Potvin method B subtleties d_labes 2011-01-31 14:24
- Potvin method B subtleties jdetlor 2011-02-01 17:17
  - Potvin method B subtleties d_labes 2011-02-02 09:15
    - Potvin method B subtleties jdetlor 2011-02-02 16:08
      - Gould d_labes 2011-02-02 16:25
        
        Gould jdetlor 2011-02-02 17:02
- Another one ...d_labes 2011-02-07 14:32
  - Oops! Helmut 2011-02-07 15:24
    - Oops! d_labes 2011-02-07 16:29
      - Oops! Helmut 2011-02-07 16:47
        
        Oops! ElMaestro 2011-02-07 17:06
        
        Oops! Helmut 2011-02-07 17:17
        
        Oops! ElMaestro 2011-02-07 18:35
        
        Simul'ants in my pants d_labes 2011-02-08 09:07
        
        Need for speed... ElMaestro 2011-02-13 10:57
        
        Need for speed... d_labes 2011-02-15 14:06
        
        Need for speed... ElMaestro 2011-02-15 17:39
        
        Pocock alpha's d_labes 2011-02-16 09:18
        
        ElMaestro's brain ElMaestro 2011-02-16 09:32
        
        ElMaestro's brain d_labes 2011-02-16 10:05
        
        ElMaestro's brain ElMaestro 2011-02-16 12:07
        
        Numbers d_labes 2011-02-16 13:45
- Bonus counter-question ElMaestro 2011-02-07 23:44
  - Speed is the question d_labes 2011-02-08 08:36
- New paper (method D for PE 0.90) Helmut 2011-04-18 12:58
  - New paper (method D for PE 0.90) d_labes 2011-04-19 08:58
    - New paper (method D for PE 0.90) Helmut 2011-04-19 14:30
    - New paper (method D for PE 0.90) ElMaestro 2011-04-19 14:49
      - Stopping criterion # futility rule Helmut 2011-04-19 15:28