Bioequivalence and Bioavailability Forum • Blind ?

Blind ? [Two-Stage / GS Designs]

posted by Ohlbe – France, 2010-10-28 01:37 (5351 d 00:45 ago) – Posting: # 6092
Views: 15,984

Dear Jack,

What's probably confusing to a number of people following this thread is what you exactly mean with "blind". In clinical trials this is usually meant as not knowing which treatment is administered to which patient/subject. In a BE trial this usually only applies to the bioanalytical lab. You can't run the statistical analysis without unblinding (even if you call the products A and B and don't tell the statistician which is the test and which is the reference, it won't make any difference).

So to keep it short, a question from a non-statistician: what do you exactly mean by blinded in this particular context ? Blinded to what ?

Regards
Ohlbe

—
Regards
Ohlbe

Complete thread:

2-stage design with interim sample size estimation d_labes 2010-10-05 15:09
- 2-stage design with interim sample size estimation Jack 2010-10-25 18:20
  - Null = bioINequivalence Helmut 2010-10-25 19:16
  - 2-stage design with interim sample size estimation d_labes 2010-10-26 13:28
    - 2-stage design with interim sample size estimation Jack 2010-10-26 18:26
      - Blind or not, Indecisions or Decisions d_labes 2010-10-27 16:01
        
        Blind or not, Indecisions or Decisions Jack 2010-10-27 18:14
        
        Blind ?Ohlbe 2010-10-27 23:37
        
        Blind ? Jack 2010-10-28 10:24
        
        Blind 2Stage Astea 2019-05-30 10:37
        
        Blind 2Stage Helmut 2019-05-30 12:56
        
        Blind 2Stage and an elephant Astea 2019-05-31 14:36
        
        Which elephant? Helmut 2019-06-02 20:14
        
        Blind interim in parallel design? Astea 2019-06-03 01:47
        
        Blind men d_labes 2019-06-05 12:23
        
        The Blind Leading the Blind Astea 2019-06-06 00:55