Bioequivalence and Bioavailability Forum • Strong Type I Error control + CI: Not yet…

Strong Type I Error control + CI: Not yet… [Two-Stage / GS Designs]

posted by Alex – Austria, 2024-01-08 17:22 (886 d 11:19 ago) – Posting: # 23822
Views: 13,153

Hi Helmut,

thanks for confirming my understanding.

Yes, as far as I understood, the paper uses ANOVA, which caused confusion at my side and was the reason for my post. I thought that I may have missed something. But I totally agree with you, the “Two-at-a-Time” approach with unequal variances would have been the better choice (but again leading to the problem of contructing RCIs for the inverse normal combination test and the need to use Potvin's algorithms).

Hope to see you again in person soon.
Alex

Complete thread:

Parallel Group Adaptive Designs Alex 2023-12-22 10:08
- Strong Type I Error control + CI: Not yet… Helmut 2023-12-22 12:01
  - Strong Type I Error control + CI: Not yet…Alex 2024-01-08 16:22
    - Strong Type I Error control + CI: Not yet… Helmut 2024-01-09 09:48
  - Strong Type I Error control + CI: Not yet… roman_max 2024-04-04 15:18
    - Parallel design: Only simulation-based methods so far Helmut 2024-04-04 20:16
      - Parallel design: Only simulation-based methods so far roman_max 2024-04-15 21:46
- Parallel Group Adaptive Designs Achievwin 2024-01-05 11:53
  - Simulations highly recommended Helmut 2024-01-05 12:40
    - Simulations highly recommended Achievwin 2024-01-08 16:55
      - Simulations mandatory Helmut 2024-01-09 09:31
        
        Simulations mandatory Achievwin 2024-01-09 21:11
        
        Reviews are confidential Helmut 2024-01-09 22:10
        
        Reviews are confidential Achievwin 2024-01-19 15:11
        
        Not accepted and for a reason… Helmut 2024-04-04 20:22
        
        Quod licet Iovi mittyri 2024-04-05 20:33
        
        Non licet bovi Helmut 2024-04-05 21:50
        
        Non licet bovi mittyri 2024-04-05 22:21
        
        Quod licet bove? Helmut 2024-04-06 07:21