Bioequivalence and Bioavailability Forum • T1E after 1st stage in Power2Stage

T1E after 1st stage in Power2Stage [Two-Stage / GS Designs]

posted by ElMaestro – Denmark, 2022-06-24 20:25 (1448 d 23:24 ago) – Posting: # 23082
Views: 7,931

Hi Mittyri,

❝ could you please guide me regarding the function to be used for T1E estimation after 1st stage of Potvin methods (Power2Stage R package)?

That would be a misnomer, I think. The T1E is a property of the testing approach. There is an alpha at stage 1 and there is an alpha at stage 2 but there is no T1E at stage 1 (or 2). There is just a well-defined T1E for the approach.
Mixing up the terms alpha and T1E is a real danger for 2-stage approaches, since in "normal" trials they are one and the same.

—
Pass or fail!
ElMaestro

Complete thread:

T1E after 1st stage in Power2Stage mittyri 2022-06-24 13:43
- T1E after 1st stage in TSDs Helmut 2022-06-24 14:33
  - T1E after 1st stage in TSDs mittyri 2022-06-24 21:12
    - T1E after 1st stage in TSDs Helmut 2022-06-25 14:07
      - Potvin C consequences mittyri 2022-06-25 23:29
        
        Potvin C consequences ElMaestro 2022-06-26 09:11
        
        Potvin C consequences mittyri 2022-06-27 13:45
        
        Potvin C consequences Helmut 2022-06-27 14:49
        
        from Potvin C to Inverse Normal mittyri 2022-06-27 17:13
        
        From Potvin C to Inverse Normal: history (and outlook?) Helmut 2022-06-27 18:54
        
        Potvin C consequences ElMaestro 2022-06-27 17:13
        
        true CV ≠ observed CV mittyri 2022-06-27 17:22
- T1E after 1st stage in Power2StageElMaestro 2022-06-24 18:25
  - T1E after 1st stage in Power2Stage mittyri 2022-06-24 21:05
    - T1E after 1st stage in Power2Stage ElMaestro 2022-06-24 22:55