Bioequivalence and Bioavailability Forum • a bug in interim.tsd.in()?

a bug in interim.tsd.in()? [Two-Stage / GS Designs]

posted by mittyri – Russia, 2018-06-12 01:27 (2567 d 04:11 ago) – Posting: # 18884
Views: 17,924

Dear Ben,

Thank you for explanations!
As I mentioned above, I was not aware that Maurer method is not just another set of alphas. After reading the manuscript I understood the concept.
I tried to simulate some data to show the approach of safety net with inverse normal vs fixed (Helmut is right, it is very popular in Russia last days as my colleagues said; of course the Sponsors are using Potvin C :-D

)

But my loop was interrupted:

interim.tsd.in(GMR1=0.89, CV1=0.2575165, n1=38)

Error in tval[, 1] : incorrect number of dimensions

In addition: Warning messages:

1: In qnorm(p2) : NaNs produced

2: In min(df) : no non-missing arguments to min; returning Inf

What is going on here?
I thought the problem with GMR1<0.9, tried to add some condition to omit the replicates with GMR1<0.9, but even that case got the same error for some replicates.

—
Kind regards,
Mittyri

Complete thread:

Finally: Exact TSD methods for 2×2 crossover designs Helmut 2018-04-21 17:17
- Exact TSD methods: Example Helmut 2018-04-21 20:33
- Finally: Exact TSD methods for 2×2 crossover designs ElMaestro 2018-04-21 20:49
  - Flow chart (without details) Helmut 2018-04-21 21:41
    - naive questions regarding new functions in Power2Stage mittyri 2018-04-28 15:54
      - Some answers Helmut 2018-04-28 17:29
      - Some more "answers" d_labes 2018-04-29 21:11
        
        clarification regarding user Power2Stage guides mittyri 2018-04-30 13:41
- Technicality: Weigths for the inverse normal approach d_labes 2018-04-25 14:19
  - Selection of w and w* Helmut 2018-04-26 09:51
    - Selection of w and w* d_labes 2018-04-26 20:02
    - Now what? w & w* examples d_labes 2018-05-09 13:53
      - Now what? w & w* examples Ben 2018-06-10 20:12
        
        Now what? w & w* examples Helmut 2018-06-11 13:57
        
        Now what? w & w* examples Ben 2018-06-12 19:14
        
        a bug in interim.tsd.in()?mittyri 2018-06-11 23:27
        
        a bug in interim.tsd.in()? Ben 2018-06-12 19:32
        
        Nonbinding futility rule d_labes 2018-06-13 16:59
        
        Bad weather? Helmut 2018-06-13 19:23
        
        NLYW? d_labes 2018-06-14 10:18
        
        Nonbinding futility rule Ben 2018-06-13 20:26
        
        Nonbinding futility rule d_labes 2018-06-14 10:47
        
        Nonbinding futility rule Ben 2018-06-15 17:58
        
        Binding / Nonbinding futility rule - alpha control d_labes 2018-06-16 19:42
        
        Binding / Nonbinding futility rule - alpha control Ben 2019-03-30 09:52