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RegisterTerminology [Two-Stage / GS Designs]
posted by Helmut 
– Vienna, Austria, 2017-02-18 17:27 (2972 d 21:07 ago) – Posting: # 17086
Views: 14,769
Hi BE-proff,
“Type 1” or “Type 2” was my proposal to introduce an unambiguous terminology. Get the paper at sci-hub.
On the contrary the Russian guideline (copypasted from the EMA’s) is ambigous (“For example, using 94.12% confidence intervals […] would be acceptable, but there are many acceptable alternatives and the choice of how much alpha to spend at the interim analysis is at the company's discretion”).
❝ Rather risky - such methods must be present in our guides otherwise our designs will be rejected...
“Type 1” or “Type 2” was my proposal to introduce an unambiguous terminology. Get the paper at sci-hub.
On the contrary the Russian guideline (copypasted from the EMA’s) is ambigous (“For example, using 94.12% confidence intervals […] would be acceptable, but there are many acceptable alternatives and the choice of how much alpha to spend at the interim analysis is at the company's discretion”).
—
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Helmut Schütz
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The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Data for 2nd stage of Potvin’s designs BE-proff 2017-02-18 06:40
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Data for 2nd stage of Potvin’s designs ElMaestro 2017-02-18 10:20
- Data for 2nd stage of Potvin’s designs BE-proff 2017-02-18 13:29
- GMR = fixed! Helmut 2017-02-18 16:23
- Data for 2nd stage of Potvin’s designs BE-proff 2017-02-18 13:29
- “Type 1” slightly higher power than “Type 2” for the same adj. α Helmut 2017-02-18 11:51
- “Type 1” slightly higher power than “Type 2” for the same adj. α BE-proff 2017-02-18 13:31
- TerminologyHelmut 2017-02-18 16:27
- Terminology Yura 2017-02-20 11:28
- Which GMR to plug in ElMaestro 2017-02-20 11:46
- Which GMR to plug in BE-proff 2017-02-21 11:35
- Which GMR to plug in ElMaestro 2017-02-21 11:47
- Which GMR to plug in BE-proff 2017-02-21 11:35
- Validated frameworks; observed GMR not relevant Helmut 2017-02-22 12:03
- Validated frameworks; observed GMR not relevant Silva 2017-03-09 01:26
- GMR, theta 0 and that all d_labes 2017-03-09 09:21
- GMR, theta 0 and that all Silva 2017-03-09 12:38
- GMR, theta 0 and that all ElMaestro 2017-03-09 12:56
- GMR, theta0 and that all d_labes 2017-03-09 13:55
- GMR, theta0 and that all Silva 2017-03-09 18:01
- GMR, theta 0 and that all Silva 2017-03-09 12:38
- GMR, theta 0 and that all d_labes 2017-03-09 09:21
- Validated frameworks; observed GMR not relevant Silva 2017-03-09 01:26
- Which GMR to plug in ElMaestro 2017-02-20 11:46
- Terminology Yura 2017-02-20 11:28
- TerminologyHelmut 2017-02-18 16:27
- “Type 1” slightly higher power than “Type 2” for the same adj. α BE-proff 2017-02-21 11:31
- “Type 1” slightly higher power than “Type 2” for the same adj. α BE-proff 2017-02-18 13:31
- Data for 2nd stage of Potvin’s designs ElMaestro 2017-02-18 10:20
Ing. Helmut Schütz