Bioequivalence and Bioavailability Forum

Impact of minimum stage 2 sample size on the TIE: example [Two-Stage / GS Designs]

posted by ElMaestro  – Denmark, 2016-12-30 18:19 (3097 d 04:44 ago) – Posting: # 16913
Views: 7,130

Hi Helmut,

I am still lost, I must confess. Perhaps it is because I am not using the power2Stage package at all.

❝ I’ll give two examples. Both at the location (n₁ 12, CV 20%) of the maximum TIE.

❝ Simulating for power (at 0.95):

1. No lower limit of n₂
   

   ❝ library(Power2Stage)
   

   ❝ power.2stage(method="B", alpha=rep(0.0294, 2), CV=0.2,
   

   ❝              n1=12, GMR=0.95, targetpower=0.8, min.n2=0)

Should this not be min.n2=2 ? Or is it the "same difference"??

Do you think you have it in your heart to explain in slow motion to a dimwit like me who read your posts quite a few times which point you are trying to prove or investigating?

Otherwise I am afraid I will need to question you next time we meet f2f. And that might not be in the distant future

Complete thread:

• Impact of minimum stage 2 sample size on the Type I Error Helmut 2016-12-30 01:22 
  • Impact of minimum stage 2 sample size on the Type I Error ElMaestro 2016-12-30 12:12
    • Impact of minimum stage 2 sample size on the TIE: example Helmut 2016-12-30 14:01
      • Impact of minimum stage 2 sample size on the TIE: exampleElMaestro 2016-12-30 17:19
        • Impact of minimum stage 2 sample size on the TIE: example Helmut 2016-12-30 18:00
          • Impact of minimum stage 2 sample size on the TIE: example ElMaestro 2016-12-30 18:50
            • Bingo! Helmut 2016-12-30 19:00