Bioequivalence and Bioavailability Forum

Advantages – performance measure [Two-Stage / GS Designs]

posted by d_labes  – Berlin, Germany, 2015-06-05 13:21 (3602 d 20:13 ago) – Posting: # 14917
Views: 19,561

Dear ElMaestro!

❝ We really need some kind of summary statistic that is the ultimate indicator of whether one method is better than the other. ...

Really good point!

Have a look into
Kieser, Rauch
"Two-stage designs for cross-over bioequivalence trials"
Stat Med 2015
DOI: 10.1002/sim.6487

They cite and use a performance score according to
Liu et al.
"Evaluating the adaptive performance of flexible sample size designs with treatment difference in an interval"
Stat Med 2008; 27:584–596.

But don't ask me for details! I haven't had a look into the last reference up to now .

Complete thread:

• Does unequal alpha distribution make sense? Dr_Dan 2015-05-19 08:29 
  • Maybe; but watch the TIE! Helmut 2015-05-28 15:04
    • Advantages d_labes 2015-06-05 09:35
      • Advantages ElMaestro 2015-06-05 10:07
        • Advantages – performance measured_labes 2015-06-05 11:21
          • Advantages – performance measure Helmut 2015-06-05 13:29
            • Advantages – performance measure d_labes 2015-06-05 21:27
              • Advantages – performance measure Helmut 2015-06-05 23:29
                • Histogram wonder d_labes 2015-06-06 12:58
                  • Histogram charlatanry Helmut 2015-06-09 13:43
                    • Histogram beauty d_labes 2015-06-09 14:55
                      • Histogram beast Helmut 2015-06-09 15:24
  • Does unequal alpha distribution make sense? Dr_Dan 2015-05-29 08:33
    • Does unequal alpha distribution make sense? ElMaestro 2015-05-29 09:31
      • Does unequal alpha distribution make sense? nobody 2015-05-29 12:56
        • Old beliefs die hard Helmut 2015-05-29 13:27
          • Old beliefs die hard nobody 2015-05-29 13:41
            • Old beliefs die hard Helmut 2015-05-29 18:08
              • Old beliefs die hard ElMaestro 2015-05-29 18:57
                • Old beliefs die hard nobody 2015-05-29 20:06
                • ♩ ♪♫♬`·.¸¸.·´`·.¸¸. Helmut 2015-06-02 01:52
                  • TSD only an option in ex­ceptional cases Dr_Dan 2015-06-02 08:00
                    • TSD only an option in ex­ceptional cases nobody 2015-06-02 09:23
                      • OT Helmut 2015-06-02 12:07
                        • OT nobody 2015-06-02 12:41
  • Banana splits Helmut 2015-06-02 00:48