Bioequivalence and Bioavailability Forum • Advantages

Advantages – performance measure [Two-Stage / GS Designs]

posted by d_labes – Berlin, Germany, 2015-06-05 13:21 (4030 d 15:45 ago) – Posting: # 14917
Views: 24,269

Dear ElMaestro!

❝ We really need some kind of summary statistic that is the ultimate indicator of whether one method is better than the other. ...

Really good point!

Have a look into
Kieser, Rauch
"Two-stage designs for cross-over bioequivalence trials"
Stat Med 2015
DOI: 10.1002/sim.6487

They cite and use a performance score according to
Liu et al.
"Evaluating the adaptive performance of flexible sample size designs with treatment difference in an interval"
Stat Med 2008; 27:584–596.

But don't ask me for details! I haven't had a look into the last reference up to now :lookaround:

—
Regards,

Detlew

Complete thread:

Does unequal alpha distribution make sense? Dr_Dan 2015-05-19 08:29
- Maybe; but watch the TIE! Helmut 2015-05-28 15:04
  - Advantages d_labes 2015-06-05 09:35
    - Advantages ElMaestro 2015-06-05 10:07
      - Advantages – performance measured_labes 2015-06-05 11:21
        
        Advantages – performance measure Helmut 2015-06-05 13:29
        
        Advantages – performance measure d_labes 2015-06-05 21:27
        
        Advantages – performance measure Helmut 2015-06-05 23:29
        
        Histogram wonder d_labes 2015-06-06 12:58
        
        Histogram charlatanry Helmut 2015-06-09 13:43
        
        Histogram beauty d_labes 2015-06-09 14:55
        
        Histogram beast Helmut 2015-06-09 15:24
- Does unequal alpha distribution make sense? Dr_Dan 2015-05-29 08:33
  - Does unequal alpha distribution make sense? ElMaestro 2015-05-29 09:31
    - Does unequal alpha distribution make sense? nobody 2015-05-29 12:56
      - Old beliefs die hard Helmut 2015-05-29 13:27
        
        Old beliefs die hard nobody 2015-05-29 13:41
        
        Old beliefs die hard Helmut 2015-05-29 18:08
        
        Old beliefs die hard ElMaestro 2015-05-29 18:57
        
        Old beliefs die hard nobody 2015-05-29 20:06
        ♩ ♪♫♬`·.¸¸.·´`·.¸¸. Helmut 2015-06-02 01:52
        
        TSD only an option in exceptional cases Dr_Dan 2015-06-02 08:00
        
        TSD only an option in exceptional cases nobody 2015-06-02 09:23
        
        OT Helmut 2015-06-02 12:07
        
        OT nobody 2015-06-02 12:41
- Banana splits Helmut 2015-06-02 00:48