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RegisterDoes unequal alpha distribution make sense? [Two-Stage / GS Designs]
Dear Helmut
For a non-statistician the whole problem is very complicated. The method according to Haybittle/Peto
Stage I: 0.001 leading to 99.8% CI
Stage II: 0.049 leading to 90.2% CI
may lead to unacceptable inflation of the TIE, so far I understood. As you explained in your pile of half-baked manuscripts you explored adjusted alphas which maintain the TIE. For a “type 1” TSD, GMR 0.95, target power 80%, α1 0.001 you found an adjusted α2 of 0.0413 suitable to maintain the patient’s risk. Using this method which kind of CI do you have for the second stage?
Stage I: 0.001 leading to 99.8% CI
Stage II: 0.0413 leading to 9?.?% CI ???
For the sample size calculation for the second stage you use the GMR 0.95 or the GMR as calculated from stage I results?
Kind regards
Dr_Dan
For a non-statistician the whole problem is very complicated. The method according to Haybittle/Peto
Stage I: 0.001 leading to 99.8% CI
Stage II: 0.049 leading to 90.2% CI
may lead to unacceptable inflation of the TIE, so far I understood. As you explained in your pile of half-baked manuscripts you explored adjusted alphas which maintain the TIE. For a “type 1” TSD, GMR 0.95, target power 80%, α1 0.001 you found an adjusted α2 of 0.0413 suitable to maintain the patient’s risk. Using this method which kind of CI do you have for the second stage?
Stage I: 0.001 leading to 99.8% CI
Stage II: 0.0413 leading to 9?.?% CI ???
For the sample size calculation for the second stage you use the GMR 0.95 or the GMR as calculated from stage I results?
Kind regards
Dr_Dan
—
Kind regards and have a nice day
Dr_Dan
Kind regards and have a nice day
Dr_Dan
Complete thread:
- Does unequal alpha distribution make sense? Dr_Dan 2015-05-19 08:29
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Maybe; but watch the TIE! Helmut 2015-05-28 15:04
- Advantages d_labes 2015-06-05 09:35
- Advantages ElMaestro 2015-06-05 10:07
- Advantages – performance measure d_labes 2015-06-05 11:21
- Advantages – performance measure Helmut 2015-06-05 13:29
- Advantages – performance measure d_labes 2015-06-05 21:27
- Advantages – performance measure Helmut 2015-06-05 23:29
- Histogram wonder d_labes 2015-06-06 12:58
- Histogram charlatanry Helmut 2015-06-09 13:43
- Histogram beauty d_labes 2015-06-09 14:55
- Histogram beast Helmut 2015-06-09 15:24
- Histogram beauty d_labes 2015-06-09 14:55
- Histogram charlatanry Helmut 2015-06-09 13:43
- Histogram wonder d_labes 2015-06-06 12:58
- Advantages – performance measure Helmut 2015-06-05 23:29
- Advantages – performance measure d_labes 2015-06-05 21:27
- Advantages – performance measure Helmut 2015-06-05 13:29
- Advantages – performance measure d_labes 2015-06-05 11:21
- Advantages ElMaestro 2015-06-05 10:07
- Advantages d_labes 2015-06-05 09:35
- Does unequal alpha distribution make sense?Dr_Dan 2015-05-29 08:33
- Does unequal alpha distribution make sense? ElMaestro 2015-05-29 09:31
- Does unequal alpha distribution make sense? nobody 2015-05-29 12:56
- Old beliefs die hard Helmut 2015-05-29 13:27
- Old beliefs die hard nobody 2015-05-29 13:41
- Old beliefs die hard Helmut 2015-05-29 18:08
- Old beliefs die hard ElMaestro 2015-05-29 18:57
- Old beliefs die hard nobody 2015-05-29 20:06
- ♩ ♪♫♬`·.¸¸.·´`·.¸¸. Helmut 2015-06-02 01:52
- TSD only an option in exceptional cases Dr_Dan 2015-06-02 08:00
- TSD only an option in exceptional cases nobody 2015-06-02 09:23
- TSD only an option in exceptional cases Dr_Dan 2015-06-02 08:00
- Old beliefs die hard ElMaestro 2015-05-29 18:57
- Old beliefs die hard Helmut 2015-05-29 18:08
- Old beliefs die hard nobody 2015-05-29 13:41
- Old beliefs die hard Helmut 2015-05-29 13:27
- Does unequal alpha distribution make sense? nobody 2015-05-29 12:56
- Does unequal alpha distribution make sense? ElMaestro 2015-05-29 09:31
- Banana splits Helmut 2015-06-02 00:48
- Maybe; but watch the TIE! Helmut 2015-05-28 15:04
Ing. Helmut Schütz