Type 1: no interim power (NL?) [Two-Stage / GS Designs]

posted by d_labes  – Berlin, Germany, 2015-02-13 15:53 (3783 d 07:07 ago) – Posting: # 14417
Views: 5,555

Dear Helmut,

❝ Bonus question: Is interim power acceptable for “type 1” TSDs?


If not, use power.2stage.fC() with arguments (powerstep = FALSE, method="B", fClower=0, ...) and simsalabim interim power has vanished :cool:!

Note: The results are totally equal to powerstep = TRUE since this step is now substitutionally done (implicitly) by the sample size estimation step.

BTW: This n2=2 at minimum is totally incomprehensible to me. One of the arguments was if not used alpha will be inflated. Seems you have shown that the opposite is true.

Regards,

Detlew

Complete thread:

UA Flag
Activity
 Admin contact
23,424 posts in 4,927 threads, 1,672 registered users;
272 visitors (0 registered, 272 guests [including 31 identified bots]).
Forum time: 00:00 CEST (Europe/Vienna)

Reach for the stars,
even if you have to stand on a cactus.    Susan Longacre

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5