Bioequivalence and Bioavailability Forum

Dear All,

Is there any specific difference between two stage and group sequential design?

I guess, group sequential design, if we limited up to two stages and keeping alpha level same for both the stages (like Method B, Potvin literature), then two stage and group sequential are same design .

Correct me if I am wrong. Still if there is a difference between group sequential and two stage design, I would like to know.

One more question regarding the difference between group sequential design and adaptive design. Is there any difference?

I guess that in adaptive design alpha level can not be the same (Method C, Potvin literature).

Correct me if I am wrong. If any other difference between group sequential and adaptive design, I would like to know.

Thanks and regards,
Niraj