Bioequivalence and Bioavailability Forum • Power for Two stage Design

Power for Two stage Design [Two-Stage / GS Designs]

posted by K2K – India, 2013-10-08 16:35 (4636 d 03:11 ago) – Posting: # 11626
Views: 22,970

Dear Sir

I am also little bit confused.

After completion of stage 1 we want to evaluate the power. If power is >= 80 evaluate BE at stage 1 (alpha=0.05) and if power < 80% evaluate BE at stage 1 (alpha=0.0294) ...............

After evaluation of power only we can plan further step (If i am wrong pls guide me). In most of your lecture and discussion you mentioned No a posteriori Power.

So In two stage study design how to evaluate the Power for our data.

Any validated method is there to evaluate the power for two stage study design or can I use PowerTOST or Winnonlin to evaluate the power.

Sorry if i m confused you and pls guide me.

Complete thread:

Potvin’s 2-stage adaptive design GSD 2012-08-17 20:56
- Potvin’s 2-stage adaptive design + RSABE/ABEL Helmut 2012-08-18 00:39
  - Potvin’s 2-stage adaptive design + RSABE/ABEL GSD 2012-08-31 16:30
    - Tough job Helmut 2012-08-31 18:37
      - Tough job GSD 2012-08-31 19:23
        
        C/D for EMA? Good luck! Helmut 2012-09-01 15:09
      - Surprise? d_labes 2012-09-05 12:57
        
        Got it. Ages for sims to complete Helmut 2012-09-05 13:35
        
        Life belt d_labes 2012-09-05 14:51
        
        Life belt Helmut 2012-09-05 15:20
  - Power for Two stage Design K2K 2013-10-07 14:43
    - Power for Two stage Design Helmut 2013-10-07 14:59
      - Power for Two stage DesignK2K 2013-10-08 14:35
        
        “Interim power” Helmut 2013-10-08 14:58
        
        “Interim power” K2K 2013-10-09 12:39
        
        Validation of PowerTOST Helmut 2013-10-09 14:10
        Phoenix/WinNonlin - power d_labes 2013-10-09 16:11
        
        Phoenix/WinNonlin - power Helmut 2013-10-09 18:19
        
        power K2K 2013-10-10 08:36