Bioequivalence and Bioavailability Forum • 3-way replicate vs. 4-way

3-way replicate vs. 4-way [GxP / QC / QA]

posted by drmuneesh – 2009-08-20 11:28 (6146 d 02:06 ago) – Posting: # 4074
Views: 10,508

Dear Helmut

It is true that there are higher chances of drop-outs if we increase the number of periods, especially when there is long washout period. But I don't really know what is more ethical: to administer N subjects four times or 1½N subjects three times? I always thought that exposing less number of subjects to IP is more ethical.

Thank you
Best Regards
Muneesh

Complete thread:

Expiry date on medicines drmuneesh 2009-08-10 16:43
- Expiry date on medicines Helmut 2009-08-10 16:52
  - Expiry date on medicines drmuneesh 2009-08-11 07:30
    - 3-way replicate vs. 4-way Helmut 2009-08-11 14:22
      - 3-way replicate vs. 4-way drmuneesh 2009-08-17 05:46
        
        3-way replicate vs. 4-way Helmut 2009-08-20 02:14
        
        3-way replicate vs. 4-waydrmuneesh 2009-08-20 09:28
        
        Ethics: no. of administrations Helmut 2009-08-20 14:05
        
        Ethics: no. of administrations drmuneesh 2009-08-21 10:43