Bioequivalence and Bioavailability Forum • 3-way replicate vs. 4-way

3-way replicate vs. 4-way [GxP / QC / QA]

posted by drmuneesh – 2009-08-17 07:46 (6147 d 10:21 ago) – Posting: # 4049
Views: 10,786

Dear HS

Thank you for the reply. We are planning 4-period replicate design to reduce the number of subjects also. Highly variable drug like risedronate having intrasubject variability of 50-80% would require too many subjects in case of 3-period design. 3-period design may be ok for drugs having intrasubject variability of 30-50%.

Please suggest if I am wrong.

Regards

Dr Muneesh Garg

Complete thread:

Expiry date on medicines drmuneesh 2009-08-10 16:43
- Expiry date on medicines Helmut 2009-08-10 16:52
  - Expiry date on medicines drmuneesh 2009-08-11 07:30
    - 3-way replicate vs. 4-way Helmut 2009-08-11 14:22
      - 3-way replicate vs. 4-waydrmuneesh 2009-08-17 05:46
        
        3-way replicate vs. 4-way Helmut 2009-08-20 02:14
        
        3-way replicate vs. 4-way drmuneesh 2009-08-20 09:28
        
        Ethics: no. of administrations Helmut 2009-08-20 14:05
        
        Ethics: no. of administrations drmuneesh 2009-08-21 10:43