Bioequivalence and Bioavailability Forum • Simulation incorporating intrasubject CV

Simulation incorporating intrasubject CV [PK / PD]

posted by jag009 – NJ, 2013-01-22 22:11 (4907 d 06:44 ago) – Posting: # 9900
Views: 11,446

Hi all,

Can someone give me some advice on how to incorporate intrasubject variation into BE simulations? For example, if one wants to simulate (monte carlo sim) a 2x2 crossover trial for a drug, one would have on hand the PK parameters obtained from fitting the PK profile with a model, the intersubject CV of each PK parameters, one can also get the intrasubject CV too. When it comes to doing the simulation, how does one incorporate the within-subject CV though?

Thanks
John

Complete thread:

Simulation incorporating intrasubject CVjag009 2013-01-22 21:11
- Simulation incorporating intrasubject CV ElMaestro 2013-01-22 22:59
  - Simulation incorporating intrasubject CV jag009 2013-01-22 23:13
    - Between ElMaestro 2013-01-23 04:52
      - Between jag009 2013-01-23 15:03
- Simulation incorporating intrasubject CV Helmut 2013-01-24 06:44
  - Simulation incorporating intrasubject CV jag009 2013-01-24 19:54
    - Bootstrap? ElMaestro 2013-01-24 20:35
      - Bootstrap? jag009 2013-01-24 22:19
        
        Bootstrap? jag009 2013-01-29 16:48