Bioequivalence and Bioavailability Forum

Dear All,

Please anyone can guide me, how to calculate lag time from subject concentration data vs time? I want manual calculation of lag time.

Following is example to calculate lag time.
Time  Concentration
(Hrs)   (ng/mL)
 0.00    0.00
 1.00    1.79
 2.00    3.48
 3.00    4.42
 3.50    4.44
 4.00    4.72
 4.33    5.12
 4.67    5.45
 5.00    4.92
 5.33    4.45
 6.00    4.12
 8.00    3.03
10.00    2.07
12.00    1.65
24.00    0.64
36.00    0.20
48.00    0.00
72.00    0.00
What is significance & interpretation of lag time in BE study? and Is there any correlation occurred between tmax & lag time?

Please Help me


Best Regards,
PANKAJ BHANGALE