Log in
RegisterApixaban PK pecularities [PK / PD]
Hi All,
According to Apixaban PIL its kinetics has some peculiarities:
1) AUC is 32% higher in patients aged over 65
2) AUC is 18% higher in women
3) AUC is 30% higher in patients with body weight below 50 kilos.
Will it be correct to say (using extrapolation) that if a slim woman aged 70 takes 2.5 mg of apixaban the "actual dose" is close to 5.0 mg?
From the point of safety the question is important
According to Apixaban PIL its kinetics has some peculiarities:
1) AUC is 32% higher in patients aged over 65
2) AUC is 18% higher in women
3) AUC is 30% higher in patients with body weight below 50 kilos.
Will it be correct to say (using extrapolation) that if a slim woman aged 70 takes 2.5 mg of apixaban the "actual dose" is close to 5.0 mg?
From the point of safety the question is important
Complete thread:
- Apixaban PK pecularitiesBE-proff 2022-03-14 20:17
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Apixaban PK pecularities dshah 2022-03-17 18:58
Ing. Helmut Schütz