Bioequivalence and Bioavailability Forum

Hello all,

When i was going through the PK parameters of an antibacterial drug, i got stuck up at one point with the background concept behind.

So basically, the three parameters are, Concentration/MIC, Time>MIC, AUC/MIC - These are the Gold standard for evaluating Antibiotic PK-PD & Dosage regimen.

My question is,
1. How the drugs(Antibiotics) are classified under one of these parameters ?
E.g - Aminoglycoside - it comes under Concentration dependent killing (i.e, Conc/MIC).
why can't this come under time/MIC ??


Please kindly help me out.

Thanks in Advance !!