Log in
RegisterVariability EV > IV (always) [PK / PD]
posted by Helmut 
– Vienna, Austria, 2020-04-15 00:56 (1851 d 02:14 ago) – Posting: # 21332
Views: 3,073
Hi John,
By “definition”?
As soon as you add an entry compartment to the system, its inherent variability will increase the overall variability, since the variability you already have (elimination and eventual distribution) will remain constant (driven only by the properties of the drug).
Sorry for the long sentence.
❝ […] IM injection tends to yield higher variability in PK, is that true? Relative to IV.
By “definition”?
As soon as you add an entry compartment to the system, its inherent variability will increase the overall variability, since the variability you already have (elimination and eventual distribution) will remain constant (driven only by the properties of the drug).
Sorry for the long sentence.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Variability in PK from IM injection jag009 2020-04-14 21:33
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Variability in PK from IM injection ElMaestro 2020-04-14 22:02
- Variability EV > IV (always)Helmut 2020-04-14 22:56
- Variability EV > IV (always) jag009 2020-04-21 21:00
Ing. Helmut Schütz