Bioequivalence and Bioavailability Forum • PK model parameters IR vs MR

PK model parameters IR vs MR [PK / PD]

posted by mittyri – Russia, 2019-09-03 18:54 (2465 d 16:01 ago) – Posting: # 20534
Views: 7,500

Hi John,

❝ 1) Is the MR equivalent to IR with respect to AUC?

No, MR AUC < IR AUC

❝ 2) How different is the Cl and V (V in particular)?

more than 10 times

❝ 3) how good is the model fit?

Internally validated with another piece of data. CV is less than 20% for all parameters
Tried to use IR params for MR dataset, during convergence they are going away. The problem is not in the model fit by itself

—
Kind regards,
Mittyri

Complete thread:

PK model parameters IR vs MR mittyri 2019-09-02 22:15
- PK model parameters IR vs MR jag009 2019-09-03 16:07
  - PK model parameters IR vs MRmittyri 2019-09-03 16:54
- PK model parameters IR vs MR ElMaestro 2019-09-03 17:43
  - PK model parameters IR vs MR mittyri 2019-09-03 18:05
- Parameter-identifiability? Helmut 2019-09-07 13:03
  - transit compartments... mittyri 2019-09-07 22:25
    - No organs in (Pop)PK Helmut 2019-09-08 10:56