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RegisterfAUC0-24 / MIC index [PK / PD]
Hi,
I'm not involved with antimicrobial stuff, but from my PK/PD understanding if the steady state is reached, the AUC won't change over different dose intervals (except of course some interoccasion variability).
So if for dose interval 8h you propose that AUCss0-8 equals to AUCss8-16, you can just multiply it to get an average value:
AUCss0-24 = AUCss0-8 * 3
Assumptions are:
- steady state
- no autoinduction or other time-varying parameters
I'm not involved with antimicrobial stuff, but from my PK/PD understanding if the steady state is reached, the AUC won't change over different dose intervals (except of course some interoccasion variability).
So if for dose interval 8h you propose that AUCss0-8 equals to AUCss8-16, you can just multiply it to get an average value:
AUCss0-24 = AUCss0-8 * 3
Assumptions are:
- steady state
- no autoinduction or other time-varying parameters
—
Kind regards,
Mittyri
Kind regards,
Mittyri
Complete thread:
- PK/PD Index PKBR 2019-01-30 14:38
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- fAUC0-24 / MIC indexmittyri 2019-01-31 23:12
Ing. Helmut Schütz