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RegisterPK/PD Index [PK / PD]
Dear all,
The PK / PD indexes are already well discussed in the literature, although they still present divergent points about the best index to be used for a given antimicrobial.
When we use the fAUC0-24 / MIC index, we have the concentration determined for 24 hours in single dose studies. But when we use only multi-dose antimicrobial in clinical practice, for example, every 6 or 8 or 12 hours, how can we evaluate this index if it mentions 0-24? Or should we do the collection experiment for 24 hours, even if this interval in no way represented sufficient exposure in the clinic? How can we evaluate this Pk/PD index for multiple dosing with intervals shorter than 24/24 hr? I'm confused. Could someone clarify this?
Thank you very much.
Edit: Category changed; see also this post #1. [Mittyri]
Please verify that category is right before posting!
The PK / PD indexes are already well discussed in the literature, although they still present divergent points about the best index to be used for a given antimicrobial.
When we use the fAUC0-24 / MIC index, we have the concentration determined for 24 hours in single dose studies. But when we use only multi-dose antimicrobial in clinical practice, for example, every 6 or 8 or 12 hours, how can we evaluate this index if it mentions 0-24? Or should we do the collection experiment for 24 hours, even if this interval in no way represented sufficient exposure in the clinic? How can we evaluate this Pk/PD index for multiple dosing with intervals shorter than 24/24 hr? I'm confused. Could someone clarify this?
Thank you very much.
Edit: Category changed; see also this post #1. [Mittyri]
Please verify that category is right before posting!
Complete thread:
- PK/PD IndexPKBR 2019-01-30 14:38
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- fAUC0-24 / MIC index mittyri 2019-01-31 23:12
Ing. Helmut Schütz