Bioequivalence and Bioavailability Forum • PK parameters from multiple doses

PK parameters from multiple doses [PK / PD]

posted by nobody – 2017-11-28 12:51 (3119 d 21:43 ago) – Posting: # 18018
Views: 12,215

Without ANY prior knowledge on the compound:

Assume you have data only for Day 15. Samples obtained on this single day (24 h), no subsequent sampling. If the t1/2 is SO long that you havn't reached steady state by Day 15, no chance to describe this t1/2 (with model or otherwise) reliable from data obtained within 24 h sampling period. ;-)

But as long as we have no idea on the prior knowledge on the compound/formulation we are talking about, all this is somewhat academic :-D

—
Kindest regards, nobody

Complete thread:

Single PK parameters from multiple PK parameters asjrm 2017-11-19 00:44
- Single PK parameters from multiple PK parameters jag009 2017-11-19 06:32
- PK parameters from multiple doses Helmut 2017-11-19 10:24
  - PK parameters from multiple doses Yura 2017-11-21 11:48
  - PK parameters from multiple doses SDavis 2017-11-24 10:59
    - PK parameters from multiple doses nobody 2017-11-24 16:07
      - PK parameters from multiple doses SDavis 2017-11-24 22:09
        
        PK parameters from multiple doses nobody 2017-11-27 14:13
        
        PK parameters from multiple doses SDavis 2017-11-28 11:34
        
        PK parameters from multiple dosesnobody 2017-11-28 11:51
        
        PK parameters from multiple doses SDavis 2017-11-28 11:54
- Single PK parameters from multiple PK parameters nobody 2017-11-21 14:54