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RegisterAntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone [PK / PD]
Hi Anky
Not for the said combination but yes, many companies have used antiemetic drugs to counteract the nausea and vomiting observed with certain anticholinesterases.
Details available at A Randomized, Crossover, Single-Dose Bioequivalence Study of Two Extended-Release Tablets of Donepezil 23 mg in Healthy Human Volunteers under Fasting and Fed States
And product was approved by USFDA
My suggestion, write to FDA before starting any study if you are doubtful.
❝
❝ Can anyone suggest which antiemetic shall be used to mitigate undesirable effect of Carbidopa, Levodopa and Entacapone tablets like nausea, vomiting in Bioequivalence study in normal human subjects?
Not for the said combination but yes, many companies have used antiemetic drugs to counteract the nausea and vomiting observed with certain anticholinesterases.
Details available at A Randomized, Crossover, Single-Dose Bioequivalence Study of Two Extended-Release Tablets of Donepezil 23 mg in Healthy Human Volunteers under Fasting and Fed States
And product was approved by USFDA
❝ Please share antiemetic drug with reference.
My suggestion, write to FDA before starting any study if you are doubtful.
—
~A happy Soul~
~A happy Soul~
Complete thread:
- AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone anky1212 2016-12-27 14:50
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone BE-proff 2016-12-27 15:08
- AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone anky1212 2016-12-27 15:43
- Antiemetic Drugs can change PK profiles mittyri 2016-12-27 17:15
- Antiemetic Drugs can change PK profiles anky1212 2016-12-27 18:02
- Antiemetic Drugs can change PK profiles mittyri 2016-12-27 19:33
- Antiemetic Drugs can change PK profiles anky1212 2016-12-27 18:02
- Antiemetic Drugs can change PK profiles mittyri 2016-12-27 17:15
- AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone anky1212 2016-12-27 15:43
- AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacaponeluvblooms 2016-12-28 08:05
- AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone BE-proff 2016-12-27 15:08
Ing. Helmut Schütz