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RegisterAntiemetic Drugs can change PK profiles [PK / PD]
Dear anky1212,
We are trying to prevent the dopamine-induced AE, right? Your subjects will be healthy, I suppose no PD in anamnesis. Due to the antagonism dopamine blockers are No1. I think metoclopramide would be even more effective due to the central effect, but not sure.
Yes, you can, but it would be not so effective as dopamine blockers.
I think no one performed such a study (LCE/LCE+Ondansetron) due to lack of physiological basis of interaction.
BTW ondansetron is mentioned as an antiemetic treatment in PD here and here
❝ Also, drugs which is dopamine antagonist may worsen pd symptoms and may not be used as antiemetic for BE OF LCE.
We are trying to prevent the dopamine-induced AE, right? Your subjects will be healthy, I suppose no PD in anamnesis. Due to the antagonism dopamine blockers are No1. I think metoclopramide would be even more effective due to the central effect, but not sure.
❝ Can we use ondansetron for BE of LCE to mitigate emesis, nausea?
Yes, you can, but it would be not so effective as dopamine blockers.
❝ But i need reference for the same which i couldn't fimd.
I think no one performed such a study (LCE/LCE+Ondansetron) due to lack of physiological basis of interaction.
BTW ondansetron is mentioned as an antiemetic treatment in PD here and here
—
Kind regards,
Mittyri
Kind regards,
Mittyri
Complete thread:
- AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone anky1212 2016-12-27 14:50
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone BE-proff 2016-12-27 15:08
- AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone anky1212 2016-12-27 15:43
- Antiemetic Drugs can change PK profiles mittyri 2016-12-27 17:15
- Antiemetic Drugs can change PK profiles anky1212 2016-12-27 18:02
- Antiemetic Drugs can change PK profilesmittyri 2016-12-27 19:33
- Antiemetic Drugs can change PK profiles anky1212 2016-12-27 18:02
- Antiemetic Drugs can change PK profiles mittyri 2016-12-27 17:15
- AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone anky1212 2016-12-27 15:43
- AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone luvblooms 2016-12-28 08:05
- AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone BE-proff 2016-12-27 15:08
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