Bioequivalence and Bioavailability Forum

Dear all,

I am struggling with an apparently simple problem, probably someone can clear my mind.

I have PK data following IV and IP administration. Concentrations following IP administration were best described by a zero-order absoprtion model. As

AUMC/AUC = MIT ("mean input time") + MRT

and for zero-order absorption MIT = absoprtion duration divided by two (=Tabs/2)

MRT_IP = AUMC_IP/AUC_IP - Tabs/2

Further,

CL_IP = F*dose/AUC_IP where F is the bioavailability.

I can estimate F by AUC_IP/AUC_IV (same doses were administered) and subsequently CL_IP which is equal to CL_IV as:

CL_IP = F*dose/AUC_IP = dose/AUC_IV = CL_IV

Does it make sense to calcualte the volume of distribution at steady-state for IP administration by MRT_IP*CL_IP?

Thanks for your efforts,
All the best,
Alex