Log in
RegisterPK linearity of propranolol [PK / PD]
Dear PJS
Propranolol is almost completely absorbed after oral administration. However, it undergoes high first-pass metabolism by the liver and on average only about 25% of propranolol reaches the systemic circulation. Propranolol is a substrate for the intestinal efflux transporter, P-glycoprotein (P-gp). However, studies suggest that P-gp is not dose-limiting for intestinal absorption of propranolol in the usual therapeutic dose range.
I hope this helps
Kind regards
Dr_Dan
Propranolol is almost completely absorbed after oral administration. However, it undergoes high first-pass metabolism by the liver and on average only about 25% of propranolol reaches the systemic circulation. Propranolol is a substrate for the intestinal efflux transporter, P-glycoprotein (P-gp). However, studies suggest that P-gp is not dose-limiting for intestinal absorption of propranolol in the usual therapeutic dose range.
I hope this helps
Kind regards
Dr_Dan
—
Kind regards and have a nice day
Dr_Dan
Kind regards and have a nice day
Dr_Dan
Complete thread:
- PK linearity of propranolol pjs 2015-05-11 14:06
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Learn to google! Helmut 2015-05-11 14:46
- Learn to google! pjs 2015-05-11 15:06
- PK linearity of propranololDr_Dan 2015-05-11 17:30
- PK linearity of propranolol pjs 2015-05-12 08:46
- PK linearity of propranolol Dr_Dan 2015-05-12 16:58
- PK linearity of propranolol pjs 2015-05-12 08:46
- Learn to google! Helmut 2015-05-11 14:46
Ing. Helmut Schütz