Bioequivalence and Bioavailability Forum

Hi Alex,

you can assume anything and will know after the experiment.
Theoretically infusion rates matter. It might be that with a fast infusion rate you saturate the meta­bo­lizing enzyme(s) (high C_max) and with a slow one (low C_max) not. You could expect a slower elimination in the former case. However, unless you torture the enzymes in such a way that the elimination switches at high concentrations to zero-order (like C₂H₅OH) you could still expect ~equal AUCs (=linear PK).
Personally I don’t think you should be too worried about infusions. Such effects are more likely if com­paring very fast releasing oral formulations with MR.