Bioequivalence and Bioavailability Forum

Magic ElMaestrolophystic Road­Show [PK / PD]

posted by nobody – 2015-02-17 17:32 (4150 d 17:17 ago) – Posting: # 14441
Views: 17,623

Hi again!

Sorry, but before we end up in the flame board

This AUC > Cmax is a rule of numb. Or maybe rule of dumb, but has nothing to do with science. Best I can imagine: Marketing. Or something like that.

AUC < Cmax will always apply, as long as I choose the timescale long enough (hours, days, weeks,...) for AUC compared to the terminal half-life of the compound. So this all is utter nonsense, as Maestro pointed out. You can not compare apples and bananas and come up with: apples are sweeter than bananas. Beyond kindergarten...

Complete thread:

• Cmax value higher than AUC msmnainar 2015-02-16 13:41 
  • Cmax value higher than AUC ElMaestro 2015-02-16 13:46
    • Cmax value higher than AUC msmnainar 2015-02-16 13:51
      • Cmax value higher than AUC ElMaestro 2015-02-16 14:01
        • Cmax value higher than AUC nobody 2015-02-16 14:23
        • Cmax value higher than AUC Dr_Dan 2015-02-17 08:11
          • Cmax value higher than AUC nobody 2015-02-17 09:38
            • Cmax value higher than AUC janmacek 2015-02-17 10:41
              • Cmax value higher than AUC nobody 2015-02-17 11:19
                • Cmax value higher than AUC msmnainar 2015-02-17 11:36
              • Magic ElMaestrolophystic Road­Show ElMaestro 2015-02-17 14:56
                • Magic ElMaestrolophystic Road­Show janmacek 2015-02-17 16:02
                  • Magic ElMaestrolophystic Road­Shownobody 2015-02-17 16:32
                  • Bizarre discussion… Helmut 2015-02-17 17:06
                    • Bizarre discussion… janmacek 2015-02-17 17:42
          • Cmax value higher than AUC Dr_Dan 2015-02-17 18:53
            • Cmax value higher than AUC nobody 2015-02-17 20:16