Bioequivalence and Bioavailability Forum • Cmax value higher than AUC

Cmax value higher than AUC [PK / PD]

posted by janmacek – Czech Republic, 2015-02-17 11:41 (4150 d 10:53 ago) – Posting: # 14436
Views: 17,609

Hi nobody and Dr_Dan,

i.v. bolus is not typically administered in a bioequivalence study. But if we want to compare numerically AUC (ng.h/ml) and Cmax (ng/ml), it is possible that Cmax > AUC if the kinetics after oral administration is rapid (like in prodrugs).

Consider the following example

Time (h)   Cmax

0.000        0

0.167        2

0.333      100

0.500       50

0.750       25

1.000       12.5

1.250        4

1.500        1

1.750        0

Cmax = 100 ng/ml
AUC = 38.3 ng·h/ml

Have a nice day!

Jan

Complete thread:

Cmax value higher than AUC msmnainar 2015-02-16 13:41
- Cmax value higher than AUC ElMaestro 2015-02-16 13:46
  - Cmax value higher than AUC msmnainar 2015-02-16 13:51
    - Cmax value higher than AUC ElMaestro 2015-02-16 14:01
      - Cmax value higher than AUC nobody 2015-02-16 14:23
      - Cmax value higher than AUC Dr_Dan 2015-02-17 08:11
        
        Cmax value higher than AUC nobody 2015-02-17 09:38
        
        Cmax value higher than AUCjanmacek 2015-02-17 10:41
        
        Cmax value higher than AUC nobody 2015-02-17 11:19
        
        Cmax value higher than AUC msmnainar 2015-02-17 11:36
        
        Magic ElMaestrolophystic RoadShow ElMaestro 2015-02-17 14:56
        
        Magic ElMaestrolophystic RoadShow janmacek 2015-02-17 16:02
        
        Magic ElMaestrolophystic RoadShow nobody 2015-02-17 16:32
        Bizarre discussion… Helmut 2015-02-17 17:06
        
        Bizarre discussion… janmacek 2015-02-17 17:42
        
        Cmax value higher than AUC Dr_Dan 2015-02-17 18:53
        
        Cmax value higher than AUC nobody 2015-02-17 20:16