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RegisterCapecitabine: 2 slopes [PK / PD]
Dear All,
I would ask you about the concentration/time curve in capecitabine study.
Here's an example from M. Mackean et al. "Phase I and Pharmacologic Study of Intermittent Twice-Daily Oral Therapy With Capecitabine in Patients With Advanced and/or Metastatic Cancer" Journal of Clinical Oncology, Vol 16, No 9, 1998: pp 2977-2985
![[image]](img/uploaded/image66.jpg)
As you can see capecitabine and 5-FU curves have 2 slopes. What is the reason of such curve shapes? fed condition or something else?
In our study we have similar results.
Edit: Category changed. [Helmut]
I would ask you about the concentration/time curve in capecitabine study.
Here's an example from M. Mackean et al. "Phase I and Pharmacologic Study of Intermittent Twice-Daily Oral Therapy With Capecitabine in Patients With Advanced and/or Metastatic Cancer" Journal of Clinical Oncology, Vol 16, No 9, 1998: pp 2977-2985
As you can see capecitabine and 5-FU curves have 2 slopes. What is the reason of such curve shapes? fed condition or something else?
In our study we have similar results.
Edit: Category changed. [Helmut]
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Kind regards,
Mittyri
Kind regards,
Mittyri
Complete thread:
- Capecitabine: 2 slopesmittyri 2013-11-01 08:30
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Enterohepatic recirculation Helmut 2013-11-01 15:11
- Enterohepatic recirculation mittyri 2013-11-21 12:23
- WinNonlin: λz Helmut 2013-11-21 14:18
- WinNonlin: λz mittyri 2013-11-22 08:25
- WinNonlin: λz Helmut 2013-11-21 14:18
- Enterohepatic recirculation mittyri 2013-11-21 12:23
- Enterohepatic recirculation Helmut 2013-11-01 15:11
Ing. Helmut Schütz