Bioequivalence and Bioavailability Forum

V corrected [🇷 for BE/BA]

posted by ElMaestro  – Denmark, 2011-01-28 16:20 (5618 d 19:00 ago) – Posting: # 6509
Views: 72,077

Dear d_labes,

thanks for spending time to educate me.
You might be right as you usually are, but it makes no sense to me. Let us for the time being forget the covariance of T and R. I am not disputing there should be a term for it, though.

With the intra-subject s_WR and s_WT only on the diagonal of V my alarm bells are ringing. Imagine a ref-replicated design; following your thinking we could fit an s_WT on the diagonal of V even though Test isn't replicated. This sounds very wrong.
Apparently others have got fits and s_WT values for 2-trt, 3-seq, 3-per designs (see e.g. here). This is fishy business.

V can be considered as ZGZ^T plus R for the model afficionados , but we need not consider it here. The intra-subject issue can be modeled in either one of them, as long as the resulting V is the right one.

The link you pasted doesn't work here. I'd be happy to read more about it though.

---

Edit: Link corrected (David changed the domain name and folder from www.boomer.org/pkin/ to www.pharmpk.com/) [Helmut]

Complete thread:

• Freedom for replicate bears d_labes 2009-04-17 12:06 
  • Freedom for replicate bears ElMaestro 2009-04-17 14:50
    • Contain does not contain d_labes 2009-04-17 15:07
  • Freedom for replicate bears ElMaestro 2009-04-18 03:45
    • Freedom incompatible with baseball bats d_labes 2009-04-20 08:42
  • Freedom for replicate bears yjlee168 2009-04-19 21:38
    • Freedom to some degree d_labes 2009-04-20 08:30
      • Freedom to some degree yjlee168 2009-04-21 14:03
        • FDA loves replicate bears? d_labes 2009-04-21 16:11
          • Cholesky factor ?! Helmut 2009-04-22 00:46
            • Cholesky factor ?! d_labes 2009-04-22 11:20
          • FDA loves replicate bears? yjlee168 2009-04-23 08:08
            • FDA loves SAS code? d_labes 2009-04-23 09:48
              • FDA loves SAS code? definitely. yjlee168 2009-04-23 10:46
                • SAS? or R? or what? d_labes 2009-04-23 15:07
                  • SAS? or R? or what? Helmut 2009-04-23 15:25
                    • SAS? or R? or what? d_labes 2009-04-23 16:06
                      • SAS? or R? or what? Helmut 2009-04-23 16:30
                  • SAS? YES; R? why not? as long as they are useful... yjlee168 2009-04-23 19:56
                    • New Forum-Category 'bear'? Helmut 2009-04-23 20:03
                      • New Forum-Category 'bear'? yjlee168 2009-04-23 20:19
                        • New Forum-Category 'R for BE/BA' Helmut 2009-04-23 20:37
                          • New Forum-Category 'R for BE/BA' yjlee168 2009-04-24 09:19
                    • Replicated again d_labes 2009-04-24 08:27
                      • Replicated again yjlee168 2009-04-24 09:26
  • getting decimals ElMaestro 2010-06-03 05:21
    • getting decimals yjlee168 2010-06-03 08:37
      • getting decimals ElMaestro 2010-06-04 01:59
  • Freedom for replicate bears ElMaestro 2011-01-27 21:50
    • lmer vs. lme d_labes 2011-01-28 09:02
      • lmer vs. lme ElMaestro 2011-01-28 09:42
        • lmer vs. lme d_labes 2011-01-28 11:37
          • V ElMaestro 2011-01-28 12:14
            • V corrected d_labes 2011-01-28 14:12
              • V correctedElMaestro 2011-01-28 15:20
                • Peculiar partial replicate d_labes 2011-01-28 16:10