Bioequivalence and Bioavailability Forum • lmer vs. lme

lmer vs. lme [🇷 for BE/BA]

posted by ElMaestro – Denmark, 2011-01-28 10:42 (5255 d 10:55 ago) – Posting: # 6505
Views: 67,320

Ahoy d_labes,

❝ But it lacks the separate estimability of the intra-subject error variance for Test and Reference, I think. As far as I know (from the R help lists) there are no plans to introduce somefink like weights in lmer().

Here are two partial outputs from lme and lmer:

With lme:
Log-restricted-likelihood: 98.12818
(...)
Random effects:
Formula: ~trt - 1 | subj
Structure: General positive-definite, Log-Cholesky parametrization
StdDev Corr
trt1 0.149013060 trt1
trt2 0.122163414 0.15
Residual 0.007643612

With lmer:
AIC BIC logLik deviance REMLdev
-170.2 -150.0 95.12 -229.3 -190.2
(...)
Random effects:
Groups Name Variance Std.Dev. Corr
subj trt1 2.2218e-02 0.1490555
trt2 1.4913e-02 0.1221188 0.150
Residual 3.3117e-05 0.0057548

Note the slightly better likelihood found by lmer. Changes quite a bit (%-wise, I mean) on the residual sigma.

—
Pass or fail!
ElMaestro

Complete thread:

Freedom for replicate bears d_labes 2009-04-17 12:06
- Freedom for replicate bears ElMaestro 2009-04-17 14:50
  - Contain does not contain d_labes 2009-04-17 15:07
- Freedom for replicate bears ElMaestro 2009-04-18 03:45
  - Freedom incompatible with baseball bats d_labes 2009-04-20 08:42
- Freedom for replicate bears yjlee168 2009-04-19 21:38
  - Freedom to some degree d_labes 2009-04-20 08:30
    - Freedom to some degree yjlee168 2009-04-21 14:03
      - FDA loves replicate bears? d_labes 2009-04-21 16:11
        
        Cholesky factor ?! Helmut 2009-04-22 00:46
        
        Cholesky factor ?! d_labes 2009-04-22 11:20
        
        FDA loves replicate bears? yjlee168 2009-04-23 08:08
        
        FDA loves SAS code? d_labes 2009-04-23 09:48
        
        FDA loves SAS code? definitely. yjlee168 2009-04-23 10:46
        
        SAS? or R? or what? d_labes 2009-04-23 15:07
        
        SAS? or R? or what? Helmut 2009-04-23 15:25
        
        SAS? or R? or what? d_labes 2009-04-23 16:06
        
        SAS? or R? or what? Helmut 2009-04-23 16:30
        
        SAS? YES; R? why not? as long as they are useful... yjlee168 2009-04-23 19:56
        
        New Forum-Category 'bear'? Helmut 2009-04-23 20:03
        
        New Forum-Category 'bear'? yjlee168 2009-04-23 20:19
        
        New Forum-Category 'R for BE/BA' Helmut 2009-04-23 20:37
        
        New Forum-Category 'R for BE/BA' yjlee168 2009-04-24 09:19
        
        Replicated again d_labes 2009-04-24 08:27
        
        Replicated again yjlee168 2009-04-24 09:26
- getting decimals ElMaestro 2010-06-03 05:21
  - getting decimals yjlee168 2010-06-03 08:37
    - getting decimals ElMaestro 2010-06-04 01:59
- Freedom for replicate bears ElMaestro 2011-01-27 21:50
  - lmer vs. lme d_labes 2011-01-28 09:02
    - lmer vs. lmeElMaestro 2011-01-28 09:42
      - lmer vs. lme d_labes 2011-01-28 11:37
        
        V ElMaestro 2011-01-28 12:14
        
        V corrected d_labes 2011-01-28 14:12
        
        V corrected ElMaestro 2011-01-28 15:20
        
        Peculiar partial replicate d_labes 2011-01-28 16:10