Bioequivalence and Bioavailability Forum

scABE and missings [🇷 for BE/BA]

posted by d_labes  – Berlin, Germany, 2011-01-21 17:19 (5630 d 13:01 ago) – Posting: # 6478
Views: 34,692

Hi ElMaestro

❝ Correction: Sorry, I meant something else than I initially wrote. It is missing values that is the concern issue because of the difference between a normal linear model and the reml approach by a mixed model.

Good question! Next question please .

To be honest: Don't know exactly. In the Progesterone guidance it is written "... Further assume that there are no missing observations ...". But only under the Heading "Example SAS Codes: fully replicated 4-way design".

My observation is that this guidance is in some instances rather vague or gives no sufficient explanation why what is done that way. Just to name "the unknown x = estimate² - stderr²" or "use GLM for partial replicate and MIXED for full replicate".

Complete thread:

• Feature suggestion for bear and PowerTOST ElMaestro 2011-01-16 19:13 
  • Sample size for widened scaled ABE limits d_labes 2011-01-17 13:19
    • 0.760 or... Helmut 2011-01-17 14:38
      • ... full precision is the question d_labes 2011-01-17 16:37
        • ... full precision is the question Helmut 2011-01-17 18:06
          • OT: Number of horns on a unicorn d_labes 2011-01-18 08:32
            • Goooogle Helmut 2011-01-18 11:44
    • Cadmium ElMaestro 2011-01-19 17:50
      • Never eaten Cadmium deliberately d_labes 2011-01-20 15:00
        • Never eaten Cadmium deliberately Helmut 2011-01-20 15:25
          • Call of duty for simulants d_labes 2011-01-20 16:15
            • Counterinuitive Helmut 2011-01-21 04:13
              • Counterintuitive d_labes 2011-01-21 08:36
                • Counterintuitive Helmut 2011-01-21 12:53
              • Counterinuitive, but ... d_labes 2011-01-21 12:12
                • Counterinuitive, but ... Helmut 2011-01-21 13:01
                  • Wow, Wow ... d_labes 2011-01-21 14:43
          • Never eaten Cadmium deliberately ElMaestro 2011-01-21 12:59
            • Simulants of the world, unite! Helmut 2011-01-21 14:05
              • Simulants of the world, unite! ElMaestro 2011-01-21 14:52
                • Hyslop, Howe, scaled ABE and that all d_labes 2011-01-21 15:28
                  • Hyslop, Howe, scaled ABE and that all ElMaestro 2011-01-21 15:45
                    • scABE and missingsd_labes 2011-01-21 16:19
                • Intuition Helmut 2011-01-21 18:41
        • Never eaten Cadmium deliberately ElMaestro 2011-01-20 15:34
          • Use of Cadmium d_labes 2011-01-20 16:06
            • Use of Cadmium ElMaestro 2011-01-20 16:52
            • Use of Cadmium ElMaestro 2011-01-20 17:53