Bioequivalence and Bioavailability Forum

Use of Cadmium [🇷 for BE/BA]

posted by ElMaestro  – Denmark, 2011-01-20 17:52 (5211 d 16:28 ago) – Posting: # 6461
Views: 30,135

Dear dlabes,

❝ Oh I see! But for what end?

❝ I understand the EMA widened acceptance ranges as applicable regardless of point estimate obtained.

A good point to make. On the other hand some people find pleasure in discussing if 0.760 is meaningful or if it should be 17 decimals. In this case I think it is a matter of doing what the guidelines says or doing what the guideline intends. I would expects this to be something you can discuss.

The code above does not assume anything other than what the ordinary (and widely accepted power routines) do. I envisage Helmut examining the acceptance range for T/R deviating from 1 and comparing it to the EMA curve and presenting such stuff at a conference. Heck if he doesn't do it, I will.

Here is a divide-and-conquer approach to the problem (simpler but not really faster ):
I_Eat_Cadmium2 <- function(P, TR, CV, alpha, N)
{
   AL3=0.9999;
   AL1=0.0001;

   while ((AL3-AL1)>0.000001)
    {
      AL2=0.5*(AL3+AL1); ##yes yes, I know, why not log midpoints etc...
      P1=Pwr223(N, alpha, AL1, 1/AL1, TR, CV);
      P2=Pwr223(N, alpha, AL2, 1/AL2, TR, CV);
      P3=Pwr223(N, alpha, AL3, 1/AL3, TR, CV);
     
      if ((P<P2) && (P>P3))
                 {
                   AL1=AL2;
                 } else AL3=AL2;
     
    }
   ##cat("Acc Lim Lo: ", AL2, "\n");
   ##cat("Acc Lim Hi: ", 1/AL2, "\n");
   AL2
}

Complete thread:

• Feature suggestion for bear and PowerTOST ElMaestro 2011-01-16 19:13 
  • Sample size for widened scaled ABE limits d_labes 2011-01-17 13:19
    • 0.760 or... Helmut 2011-01-17 14:38
      • ... full precision is the question d_labes 2011-01-17 16:37
        • ... full precision is the question Helmut 2011-01-17 18:06
          • OT: Number of horns on a unicorn d_labes 2011-01-18 08:32
            • Goooogle Helmut 2011-01-18 11:44
    • Cadmium ElMaestro 2011-01-19 17:50
      • Never eaten Cadmium deliberately d_labes 2011-01-20 15:00
        • Never eaten Cadmium deliberately Helmut 2011-01-20 15:25
          • Call of duty for simulants d_labes 2011-01-20 16:15
            • Counterinuitive Helmut 2011-01-21 04:13
              • Counterintuitive d_labes 2011-01-21 08:36
                • Counterintuitive Helmut 2011-01-21 12:53
              • Counterinuitive, but ... d_labes 2011-01-21 12:12
                • Counterinuitive, but ... Helmut 2011-01-21 13:01
                  • Wow, Wow ... d_labes 2011-01-21 14:43
          • Never eaten Cadmium deliberately ElMaestro 2011-01-21 12:59
            • Simulants of the world, unite! Helmut 2011-01-21 14:05
              • Simulants of the world, unite! ElMaestro 2011-01-21 14:52
                • Hyslop, Howe, scaled ABE and that all d_labes 2011-01-21 15:28
                  • Hyslop, Howe, scaled ABE and that all ElMaestro 2011-01-21 15:45
                    • scABE and missings d_labes 2011-01-21 16:19
                • Intuition Helmut 2011-01-21 18:41
        • Never eaten Cadmium deliberately ElMaestro 2011-01-20 15:34
          • Use of Cadmium d_labes 2011-01-20 16:06
            • Use of CadmiumElMaestro 2011-01-20 16:52
            • Use of Cadmium ElMaestro 2011-01-20 17:53