Bioequivalence and Bioavailability Forum

Dear Yung-jin,

I have some another ones, but more bullet proofs rather than new features:

In the NCA module in choosing one of the automatically methods the user is left with errors not so easy to figure out where they came from in the following instances:

• TTT rule and their combinations if one (or more) curve(s) have no points or n<2 after 2*tmax.
  
• AIC / adjR2 as fit criterion if only n<2 points are left.

IMHO it would be wise and more smart to test these cases and throw a warning in user understandable words for those cases and continue(!) with the evaluation of the remaining concentration time curves.
Eventually it would be best to have some fall-back if a method can't applied. F.i. use the points after Cmax if TTT does not yield at least 3 points, use eventually even Cmax, tmax if otherwise n<2 or some similar. Of course with a warning to the user.

Moreover: In the manual selection of time points I have observed:

• Sometimes the very last point could not be selected. But unfortunately I can't reproduce it because I have forgotten which dataset (seem's Alzheimer is knocking on door ). If I remember I will send you the data.
  
• It would be wise for the naive user not to allow choosing points before tmax.

BTW: If you have very much spare time I would highly recommend to refactor the bear code. It's a nightmare to make a code inspection and it must be a nightmare for you to maintain it, I suppose. I know it's naturally grown during development, but ...