Bioequivalence and Bioavailability Forum • Parallel groups in bear

Parallel groups in bear - CIs [🇷 for BE/BA]

posted by yjlee168 – Kaohsiung, Taiwan, 2010-04-26 01:29 (5535 d 15:28 ago) – Posting: # 5218
Views: 62,479

Dear d_labes,

❝ There is a hint I meanwhile discovered:

❝ Also the summary() function works on the lme-model intervals() does not:

❝ > intervals(lmeModel, level=0.9)

❝ Error in intervals.lme(lmeModel) :


❝   Cannot get confidence intervals on var-cov components: Non-positive

❝ definite approximate variance-covariance.

I got the following results for ln(Cmax) using built-in dataset for parallel study in bear v2.4.2 with the model of lme(lnCmax ~ drug, random=~1|subj, data=TotalData, method="REML").

Approximate 90% confidence intervals



 Fixed effects:

                  lower       est.     upper

(Intercept)  7.28570851 7.35203371 7.4183589

drug2       -0.08362165 0.00848616 0.1005940

attr(,"label")

[1] "Fixed effects:"



 Random Effects:

  Level: subj 

                       lower      est.        upper

sd((Intercept)) 1.185598e-13 0.1310857 144934894939



 Within-group standard error:

       lower         est.        upper 

1.124716e-87 4.915712e-02 2.148474e+84

—
All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

Parallel bears meeting at random in infinity d_labes 2010-04-22 11:43
- Parallel bears meeting at random in infinity ElMaestro 2010-04-22 12:53
  - Parallel groups in bear - CIs d_labes 2010-04-22 14:00
    - Parallel groups in bear - CIs ElMaestro 2010-04-22 21:47
      - Parallel groups in bear - CIs d_labes 2010-04-23 09:09
    - Parallel groups in bear - CIsyjlee168 2010-04-25 23:29
- Parallel bears meeting at random in infinity yjlee168 2010-04-22 23:09
  - Modelling Parallel bears d_labes 2010-04-23 09:12
    - Modelling Parallel bears yjlee168 2010-04-23 21:14
      - Validating vs. WinNonlin... Helmut 2010-04-24 00:28
        
        Validating vs. WinNonlin... yjlee168 2010-04-24 19:36
        Validating vs. WinNonlin... yjlee168 2010-04-26 00:09
        
        Validating vs. WinNonlin... Helmut 2010-04-26 01:29
        
        WNL in replicate BE yjlee168 2010-04-26 08:59
        
        WNL in replicate BE Helmut 2010-04-26 16:15
      - Modelling Parallel bears yjlee168 2010-04-25 19:34
        
        Modelling Parallel bears ElMaestro 2010-04-25 20:40
        Dataset Helmut 2010-04-25 22:38
        
        Dataset yjlee168 2010-04-25 22:44
        
        Dataset Helmut 2010-04-26 01:13
        
        Dataset yjlee168 2010-04-26 08:16
        
        NCA → Statistical analysis for parallel study Helmut 2010-04-26 13:12
        
        NCA → Statistical analysis for parallel study yjlee168 2010-04-26 18:43
        
        dilemma yjlee168 2010-04-26 08:41
        Equal variances d_labes 2010-04-26 09:04
        
        Equal variances yjlee168 2010-04-26 09:22
        
        GLM = Equal variances d_labes 2010-04-26 13:29
        
        GLM = Equal variances Helmut 2010-04-26 14:45
        
        I'm a believer d_labes 2010-04-26 15:58
        
        I'm a believer Helmut 2010-04-26 16:31
        
        Equal variances Helmut 2010-04-26 12:55
        
        gls() for unequal variances? d_labes 2010-04-26 16:36
        
        gls() for unequal variances? Helmut 2010-04-26 17:00
        Sims Helmut 2010-04-27 01:36
        
        Sandwich - Simsalabim d_labes 2010-04-28 10:58
        
        Sandwich - Simsalabim Helmut 2010-04-28 14:19
        parametrization of R function rlnorm martin 2010-05-02 18:22
        
        Mean of log-normal d_labes 2010-05-03 16:22
        parametrization of R function rlnorm ElMaestro 2013-07-26 21:42
        
        Martin‽ Helmut 2013-07-28 02:01