Bioequivalence and Bioavailability Forum • Parallel groups in bear

Parallel groups in bear - CIs [🇷 for BE/BA]

posted by d_labes – Berlin, Germany, 2010-04-23 11:09 (5895 d 12:37 ago) – Posting: # 5192
Views: 67,987

Dear Old saylor,

❝ In this case, I would be inclined to imagine that the error-sigma² plus subject-sigma² would equal the residual error from an anova on lm(lnAUC0t~drug) or something like that.

Full ACK.

To verify this (bear v 2.4.1 parallel group dataset):
'Mixed effects model'

Random effects:

 Formula: ~1 | subj

        (Intercept)  Residual

StdDev:   0.2396947 0.0898856   sqrt(0.2396947^2+ 0.0898856^2)=0.2559941 



Fixed effects: lnAUC0t ~ drug 

              Value  Std.Error DF  t-value p-value

(Intercept) 7.10189 0.08095245 18 87.72916  0.0000

drug2       0.01594 0.11448405 18  0.13923  0.8908

ElGrandeEM model:

Call:

lm(formula = lnAUC0t ~ drug, data = TotalData)



...



Coefficients:

            Estimate Std. Error t value Pr(>|t|)    

(Intercept)  7.10189    0.08095  87.729   <2e-16 ***

drug2        0.01594    0.11448   0.139     0.89    



Residual standard error: 0.256 on 18 degrees of freedom

Multiple R-squared: 0.001076,   Adjusted R-squared: -0.05442 

F-statistic: 0.01939 on 1 and 18 DF,  p-value: 0.8908

Note the totally identical results for the 'drug' effects.

—
Regards,

Detlew

Complete thread:

Parallel bears meeting at random in infinity d_labes 2010-04-22 11:43
- Parallel bears meeting at random in infinity ElMaestro 2010-04-22 12:53
  - Parallel groups in bear - CIs d_labes 2010-04-22 14:00
    - Parallel groups in bear - CIs ElMaestro 2010-04-22 21:47
      - Parallel groups in bear - CIsd_labes 2010-04-23 09:09
    - Parallel groups in bear - CIs yjlee168 2010-04-25 23:29
- Parallel bears meeting at random in infinity yjlee168 2010-04-22 23:09
  - Modelling Parallel bears d_labes 2010-04-23 09:12
    - Modelling Parallel bears yjlee168 2010-04-23 21:14
      - Validating vs. WinNonlin... Helmut 2010-04-24 00:28
        
        Validating vs. WinNonlin... yjlee168 2010-04-24 19:36
        Validating vs. WinNonlin... yjlee168 2010-04-26 00:09
        
        Validating vs. WinNonlin... Helmut 2010-04-26 01:29
        
        WNL in replicate BE yjlee168 2010-04-26 08:59
        
        WNL in replicate BE Helmut 2010-04-26 16:15
      - Modelling Parallel bears yjlee168 2010-04-25 19:34
        
        Modelling Parallel bears ElMaestro 2010-04-25 20:40
        Dataset Helmut 2010-04-25 22:38
        
        Dataset yjlee168 2010-04-25 22:44
        
        Dataset Helmut 2010-04-26 01:13
        
        Dataset yjlee168 2010-04-26 08:16
        
        NCA → Statistical analysis for parallel study Helmut 2010-04-26 13:12
        
        NCA → Statistical analysis for parallel study yjlee168 2010-04-26 18:43
        
        dilemma yjlee168 2010-04-26 08:41
        Equal variances d_labes 2010-04-26 09:04
        
        Equal variances yjlee168 2010-04-26 09:22
        
        GLM = Equal variances d_labes 2010-04-26 13:29
        
        GLM = Equal variances Helmut 2010-04-26 14:45
        
        I'm a believer d_labes 2010-04-26 15:58
        
        I'm a believer Helmut 2010-04-26 16:31
        
        Equal variances Helmut 2010-04-26 12:55
        
        gls() for unequal variances? d_labes 2010-04-26 16:36
        
        gls() for unequal variances? Helmut 2010-04-26 17:00
        Sims Helmut 2010-04-27 01:36
        
        Sandwich - Simsalabim d_labes 2010-04-28 10:58
        
        Sandwich - Simsalabim Helmut 2010-04-28 14:19
        parametrization of R function rlnorm martin 2010-05-02 18:22
        
        Mean of log-normal d_labes 2010-05-03 16:22
        parametrization of R function rlnorm ElMaestro 2013-07-26 21:42
        
        Martin‽ Helmut 2013-07-28 02:01